Deutsche Bank AG
Taunusanlage 12, D-60325
Frankfurt am Main
Federal Republic of Germany



Jeffrey A. Ruiz
Vice President
Telephone: (212) 469-3667


                                             August 8, 2003
SEC Document Control
450 Fifth Street, N.W.
Washington, DC  20549
Attn:  Filing Desk


Dear Sir or Madame:

         Re:  Filing of Schedule 13G - La Jolla Pharmaceutical Co



 Pursuant to Rule 13d-1 of the Securities Exchange Act of 1934, attached is one
copy of Schedule 13G with respect to the common stock of the above referenced
corporation.

Please acknowledge your receipt of the Schedule 13G by return e-mail
confirmation.

                               Sincerely,



                               Jeffrey A. Ruiz







Enclosures







                              UNITED STATES
                   SECURITIES AND EXCHANGE COMMISSION
                         Washington, D.C. 20549

                                  SCHEDULE 13G

                               (Amendment No. 4)

                Under the Securities Exchange Act of 1934

                        La Jolla Pharmaceutical Co
                 ---------------------------------------
                             NAME OF ISSUER:


                     Common Stock ($0.001 Par Value)
                 ---------------------------------------
                      TITLE OF CLASS OF SECURITIES

                                 503459109
                 ---------------------------------------
                              CUSIP NUMBER


                                July 31,2003
                 ---------------------------------------
             (Date of Event Which Requires Filing of this Statement)


         Check the appropriate box to designate the rule pursuant to which this
         Schedule is filed:

                  [X] Rule 13d-1(b)

                  [ ] Rule 13d-1(c)

                  [ ] Rule 13d-1(d)










1. NAME OF REPORTING PERSONS
    S.S. OR I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS

         Deutsche Bank AG*

2.       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (A) [ ]
         (B)       [ ]

3.       SEC USE ONLY

4.       CITIZENSHIP OR PLACE OF ORGANIZATION

    Federal Republic of Germany

NUMBER OF         5.       SOLE VOTING POWER
SHARES                     2,060,000
BENEFICIALLY      6.       SHARED VOTING POWER
OWNED BY                   0
EACH              7.       SOLE DISPOSITIVE POWER
REPORTING                  2,070,000
PERSON WITH       8.       SHARED DISPOSITIVE POWER
                                        0

9. AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

         2,070,000

10.CHECK BOX IF THE AGGREGATE AMOUNT IN ROW 9 EXCLUDES CERTAIN
   SHARES [ ]

11.PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

        4.87 %

12. TYPE OF REPORTING PERSON

         HC, CO, BK


     * In accordance with Securities Exchange Act Release No. 39538 (January 12,
     1998), this termination filing reflects the securities beneficially owned
     by the Private Clients and Asset Management business group ("PCAM") of
     Deutsche Bank AG and its subsidiaries and affiliates (collectively,
     "DBAG"). This filing does not reflect securities, if any, beneficially
     owned by any other business group of DBAG. Consistent with Rule 13d-4 under
     the Securities Exchange Act of 1934 ("Act"), this filing shall not be
     construed as an admission that PCAM is, for purposes of Section 13(d) under
     the Act, the beneficial owner of any securities covered by the filing.




Item 1(a).        Name of Issuer:

                  La Jolla Pharmaceutical Co. (the "Issuer")

Item 1(b).        Address of Issuer's Principal Executive Offices:

                  The address of the Issuer's principal executive offices is:

                  6455 Nancy Ridge Drive, San Diego, CA 92121.

Item 2(a).        Name of Person Filing:

                  This statement is filed on behalf of Deutsche Bank AG,
                  ("Reporting Person").

Item 2(b).        Address of Principal Business Office or, if none, Residence:

                  The principal place of business of the Reporting Person is:

                            Taunusanlage 12, D-60325
                           Frankfurt am Main
                           Federal Republic of Germany

Item 2(c).        Citizenship:

                  The citizenship of the Reporting Person is set forth on the

                  cover page.

Item 2(d).        Title of Class of Securities:

                  The title of the securities is common stock, $0.001 par value

                  ("Common Stock").

Item 2(e).        CUSIP Number:

                  The CUSIP number of the Common Stock is set forth on the cover

                  page.

Item 3.          If this statement is filed pursuant to Rules 13d-1(b), or

                 13d-2(b) or (c), check whether the person filing is a:

                 (a)[ ] Broker or dealer registered under section 15 of the
                        Act;

                 (b)[ ] Bank as defined in section 3(a)(6) of the Act;



                 (c)[ ] Insurance Company as defined in section 3(a)(19)
                    of the Act;

                 (d)[ ] Investment Company registered under section 8
                    of the Investment Company Act of 1940;

                 (e)[ ] An investment adviser in accordance with Rule 13d-1(b)
                    (1)(ii)(E);



                 (f)[ ]An employee benefit plan, or endowment fund in
                     accordance with Rule 13d-1 (b)(1)(ii)(F);

                 (g) [X]parent holding company or control person in
                     accordance with Rule 13d-1 (b)(1)(ii)(G);

                        Deutsche Bank AG

                 (h)[ ]A savings association as defined in section
                     3(b) of the Federal Deposit Insurance Act;

                 (i)[ ]A church plan that is excluded from the
                     definition of an investment company under section
                     3(c)(14) of the Investment Company Act of 1940;

                 (j)[ ] Group, in accordance with Rule 13d-1 (b)(1)(ii)(J).


Item 4.           Ownership.

                 (a)  Amount beneficially owned:

                  The Reporting Person owns the amount of the Common Stock as
                  set forth on the cover page.

                 (b)  Percent of class:

                  The Reporting Person owns the percentage of the Common Stock
                  as set forth on the cover page.

                 (c) Number of shares as to which such person has:






                (i) sole power to vote or to direct the vote:

                           The Reporting Person has the sole power to vote or
                           direct the vote of the Common Stock as set forth on
                           the cover page.

                           (ii) shared power to vote or to direct the vote:

                           The Reporting Person has the shared power to vote or
                           direct the vote of the Common Stock as set forth on
                           the cover page.

                           (iii) sole power to dispose or to direct the
disposition of:

                           The Reporting Person has the sole power to dispose or
                           direct the disposition of the Common Stock as set
                           forth on the cover page.

                           (iv) shared power to dispose or to direct the
disposition of:

                           The Reporting Person has the shared power to dispose
                           or direct the disposition of the Common Stock as set
                           forth on the cover page.

Item 5.           Ownership of Five Percent or Less of a Class.

                           If this statement is being filed to report the fact
                  that as of the date hereof the reporting person has ceased to
                  be the beneficial owner of more than five percent of the class
                  of securities, check the following [X].


Item 6.           Ownership of More than Five Percent on Behalf of Another
                  Person.

                  Not applicable.

Item 7.           Identification and Classification of the Subsidiary Which
                  Acquired the Security BeingReported on by the Parent Holding
                  Company.

                  Not applicable.

Item 8.           Identification and Classification of Members of the Group.

                  Not applicable.

Item 9.           Notice of Dissolution of Group.

                  Not applicable.

Item 10. Certification.

By signing below I certify that, to the best of my knowledge and belief, the
securities referred to above were acquired and are held in the ordinary course
of business and were not acquired and are not held for the purpose of or with
the effect of changing or influencing the control of the issuer of the
securities and were not acquired and are not held in connection with or as a
participant in any transaction having that purpose or effect.

                                            SIGNATURE

                  After reasonable inquiry and to the best of my knowledge and
belief, I certify that the information set forth in this statement is true,
complete and correct.
                                    DEUTSCHE BANK AG


                                    By: /s/ Jeffrey A. Ruiz
                                    Name: Jeffrey A. Ruiz
                                    Title: Vice President






Dated: 8/8/03