UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549


                                  SCHEDULE 13G

                   UNDER THE SECURITIES EXCHANGE ACT OF 1934
                               (AMENDMENT NO. 1)*

                         Keryx Biopharmaceuticals Inc.
-------------------------------------------------------------------------------
                                (Name of Issuer)

                    Common Stock, $0.001 Par Value Per Share
-------------------------------------------------------------------------------
                         (Title of Class of Securities)

                                   492515101
                                   ---------
                                 (CUSIP Number)

                               December 31, 2004
                               -----------------
                      (Date of Event which Requires Filing
                               of this Statement)



Check the appropriate box to designate the rule pursuant to which this Schedule
is filed:

                  [ ]      Rule 13d-1(b)
                  [X]      Rule 13d-1(c)
                  [ ]      Rule 13d-1(d)



  *The remainder of this cover page shall be filled out for a reporting person's
  initial filing on this form with respect to the subject class of securities,
  and for any subsequent amendment containing information which would alter the
  disclosures provided in a prior cover page.

  The information required on the remainder of this cover page shall not be
  deemed to be "filed" for the purpose of Section 18 of the Securities Exchange
  Act of 1934 ("Act") or otherwise subject to the liabilities of that section of
  the Act but shall be subject to all other provisions of the Act (however, see
  the Notes).




                                  Page 1 of 13



----------------------                                  -----------------------
CUSIP No. 492515101                   13G               Page  2  of  13  Pages
----------------------                                  -----------------------

---------- --------------------------------------------------------------------
        1  NAME OF REPORTING PERSON
           I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

           S.A.C. Capital Advisors, LLC
---------- --------------------------------------------------------------------
        2  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                              (a) / /
 
                                                              (b) /X/

---------- --------------------------------------------------------------------
        3  SEC USE ONLY


---------- --------------------------------------------------------------------
        4  CITIZENSHIP OR PLACE OF ORGANIZATION

           Delaware
--------------------- ----- ---------------------------------------------------
      NUMBER OF          5  SOLE VOTING POWER
        SHARES
     BENEFICIALLY           0
        OWNED         ----- ---------------------------------------------------
          BY             6  SHARED VOTING POWER                                
         EACH                                                                  
      REPORTING             1,821,506* (see Item 4)                            
        PERSON        ----- ---------------------------------------------------
         WITH            7  SOLE DISPOSITIVE POWER                             
                                                                               
                            0
                      ----- ---------------------------------------------------
                         8  SHARED DISPOSITIVE POWER                           
                                                                               
                            1,821,506* (see Item 4)                            
---------- --------------------------------------------------------------------
        9  AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

           1,821,506* (see Item 4)
---------- --------------------------------------------------------------------
       10  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES

           |_|
---------- --------------------------------------------------------------------
       11  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

           5.6% (see Item 4)
---------- --------------------------------------------------------------------
       12  TYPE OF REPORTING PERSON*

           00
---------- --------------------------------------------------------------------
                       *SEE INSTRUCTION BEFORE FILLING OUT



                                  Page 2 of 13



----------------------                                  -----------------------
CUSIP No. 492515101                   13G               Page  3  of  13  Pages
----------------------                                  -----------------------

---------- --------------------------------------------------------------------
        1  NAME OF REPORTING PERSON
           I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

           S.A.C. Capital Management, LLC
---------- --------------------------------------------------------------------
        2  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                              (a) / /

                                                              (b) /X/

---------- --------------------------------------------------------------------
        3  SEC USE ONLY
---------- --------------------------------------------------------------------
        4  CITIZENSHIP OR PLACE OF ORGANIZATION

           Delaware
-------------------- ------ ---------------------------------------------------
      NUMBER OF          5  SOLE VOTING POWER
       SHARES
    BENEFICIALLY            0
        OWNED        ------ ---------------------------------------------------
         BY              6  SHARED VOTING POWER                                
        EACH                                                                   
      REPORTING             1,821,506* (see Item 4)                            
       PERSON        ------ ---------------------------------------------------
        WITH             7  SOLE DISPOSITIVE POWER                             
                                                                               
                            0                                      
                     ------ ---------------------------------------------------
                         8  SHARED DISPOSITIVE POWER                           
                                                                               
                            1,821,506* (see Item 4)                            
---------- --------------------------------------------------------------------
        9  AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

           1,821,506* (see Item 4)
---------- --------------------------------------------------------------------
        10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES

           |_|
---------- --------------------------------------------------------------------
       11  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

           5.6% (see Item 4)
---------- --------------------------------------------------------------------
       12  TYPE OF REPORTING PERSON*

           00
---------- --------------------------------------------------------------------
                       *SEE INSTRUCTION BEFORE FILLING OUT

                                  Page 3 of 13



----------------------                                  -----------------------
CUSIP No. 492515101                   13G               Page  4  of  13  Pages
----------------------                                  -----------------------

---------- --------------------------------------------------------------------
        1  NAME OF REPORTING PERSON
           I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

           S.A.C. Capital Associates, LLC
---------- --------------------------------------------------------------------
        2  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                 (a) / /

                                                                 (b) /X/

---------- --------------------------------------------------------------------
        3  SEC USE ONLY


---------- --------------------------------------------------------------------
        4  CITIZENSHIP OR PLACE OF ORGANIZATION

           Anguilla, British West Indies
-------------------- ------ ---------------------------------------------------
      NUMBER OF          5  SOLE VOTING POWER
       SHARES
    BENEFICIALLY            0
        OWNED        ------ ---------------------------------------------------
         BY              6  SHARED VOTING POWER                                
        EACH                                                                   
      REPORTING             1,245,000 (see Item 4)                             
       PERSON        ------ ---------------------------------------------------
        WITH             7  SOLE DISPOSITIVE POWER                             
                                                                               
                            0                                      
                     ------ ---------------------------------------------------
                         8  SHARED DISPOSITIVE POWER                           
                                                                               
                            1,245,000 (see Item 4)                             
---------- --------------------------------------------------------------------
        9  AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

           1,245,000 (see Item 4)
---------- --------------------------------------------------------------------
       10  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES

           |_|
---------- --------------------------------------------------------------------
       11  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

           4.0% (see Item 4)
---------- --------------------------------------------------------------------
       12  TYPE OF REPORTING PERSON*

           00
---------- --------------------------------------------------------------------
                       *SEE INSTRUCTION BEFORE FILLING OUT

                                  Page 4 of 13



----------------------                                  -----------------------
CUSIP No. 492515101                   13G               Page  5  of  13  Pages
----------------------                                  -----------------------

---------- --------------------------------------------------------------------
        1  NAME OF REPORTING PERSON
           I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

           S.A.C. Healthco Fund, LLC
---------- --------------------------------------------------------------------
        2  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                              (a) / /

                                                              (b) /X/

---------- --------------------------------------------------------------------
        3  SEC USE ONLY
---------- --------------------------------------------------------------------
        4  CITIZENSHIP OR PLACE OF ORGANIZATION

           Anguilla, British West Indies
-------------------- ------ ---------------------------------------------------
      NUMBER OF          5  SOLE VOTING POWER
       SHARES
    BENEFICIALLY            0
        OWNED        ------ ---------------------------------------------------
         BY              6  SHARED VOTING POWER                                
        EACH                                                                   
      REPORTING             514,588* (see Item 4)                              
       PERSON        ------ ---------------------------------------------------
        WITH             7  SOLE DISPOSITIVE POWER                             
                                                                               
                            0                                      
                     ------ ---------------------------------------------------
                         8  SHARED DISPOSITIVE POWER                           
                                                                               
                            514,588* (see Item 4)                              
---------- --------------------------------------------------------------------
        9  AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

           514,588* (see Item 4)
---------- --------------------------------------------------------------------
       10  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES

           |_|
---------- --------------------------------------------------------------------
       11  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

           1.6% (see Item 4)
---------- --------------------------------------------------------------------
       12  TYPE OF REPORTING PERSON*

           00
---------- --------------------------------------------------------------------
                       *SEE INSTRUCTION BEFORE FILLING OUT


                                  Page 5 of 13




----------------------                                  -----------------------
CUSIP No. 492515101                   13G               Page  6  of  13  Pages
----------------------                                  -----------------------

---------- --------------------------------------------------------------------
        1  NAME OF REPORTING PERSON
           I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

           S.A.C. MultiQuant Fund, LLC
---------- --------------------------------------------------------------------
        2  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                           (a) / /

                                                           (b) /X/

---------- --------------------------------------------------------------------
        3  SEC USE ONLY
---------- --------------------------------------------------------------------
        4  CITIZENSHIP OR PLACE OF ORGANIZATION

           Anguilla, British West Indies
-------------------- ------ ---------------------------------------------------
      NUMBER OF          5  SOLE VOTING POWER
       SHARES
    BENEFICIALLY            0
        OWNED        ------ ---------------------------------------------------
         BY              6  SHARED VOTING POWER                                
        EACH                                                                   
      REPORTING             61,800 (see Item 4)                                
       PERSON        ------ ---------------------------------------------------
        WITH             7  SOLE DISPOSITIVE POWER                             
                                                                               
                            0                                      
                     ------ ---------------------------------------------------
                         8  SHARED DISPOSITIVE POWER                           
                                                                               
                            61,800 (see Item 4)                                
---------- --------------------------------------------------------------------
        9  AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

           61,800 (see Item 4)
---------- --------------------------------------------------------------------
       10  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES

           |_|
---------- --------------------------------------------------------------------
       11  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

           Less than 0.2% (see Item 4)
---------- --------------------------------------------------------------------
       12  TYPE OF REPORTING PERSON*

           00
---------- --------------------------------------------------------------------
                       *SEE INSTRUCTION BEFORE FILLING OUT


                                  Page 6 of 13




----------------------                                  -----------------------
CUSIP No. 492515101                   13G               Page  7  of  13  Pages
----------------------                                  -----------------------

---------- --------------------------------------------------------------------
        1  NAME OF REPORTING PERSON
           I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

           Steven A. Cohen
---------- --------------------------------------------------------------------
        2  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                          (a) / /

                                                          (b) /X/

---------- --------------------------------------------------------------------
        3  SEC USE ONLY
---------- --------------------------------------------------------------------
        4  CITIZENSHIP OR PLACE OF ORGANIZATION

           United States
-------------------- ------ ---------------------------------------------------
      NUMBER OF          5  SOLE VOTING POWER
       SHARES
    BENEFICIALLY            0
        OWNED        ------ ---------------------------------------------------
         BY              6  SHARED VOTING POWER                                
        EACH                                                                   
      REPORTING             1,821,506* (see Item 4)                            
       PERSON        ------ ---------------------------------------------------
        WITH             7  SOLE DISPOSITIVE POWER                             
                                                                               
                            0                                      
                     ------ ---------------------------------------------------
                         8  SHARED DISPOSITIVE POWER                           
                                                                               
                            1,821,506* (see Item 4)                            
---------- --------------------------------------------------------------------
        9  AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

           1,821,506* (see Item 4)
---------- --------------------------------------------------------------------
       10  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES

           |_|
---------- --------------------------------------------------------------------
       11  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

           5.6% (see Item 4)
---------- --------------------------------------------------------------------
       12  TYPE OF REPORTING PERSON*

           IN
---------- --------------------------------------------------------------------
                       *SEE INSTRUCTION BEFORE FILLING OUT



                                  Page 7 of 13





ITEM 1(A)      NAME OF ISSUER:
               --------------

               Keryx Biopharmaceuticals Inc.

ITEM 1(B)      ADDRESS OF ISSUER'S PRINCIPAL EXECUTIVE OFFICES:
               -----------------------------------------------

               750 Lexington Avenue
               New York, New York 10022

ITEMS 2(A)     NAME OF PERSON FILING:

               This statement is filed by: (i) S.A.C. Capital Advisors, LLC,
               ("SAC Capital Advisors") with respect to Shares beneficially
               owned by S.A.C. Capital Associates, LLC ("SAC Capital
               Associates"), S.A.C. Healthco Fund, LLC ("SAC Healthco") and
               S.A.C. MultiQuant Fund, LLC ("SAC MultiQuant"); (ii) S.A.C.
               Capital Management, LLC, ("SAC Capital Management") with
               respect to Shares beneficially owned by SAC Capital
               Associates, SAC Healthco and SAC MultiQuant; (iii) SAC Capital
               Associates with respect to Shares beneficially owned by it;
               (iv) SAC Healthco with respect to Shares beneficially owned by
               it; (v) SAC MultiQuant with respect to Shares beneficially
               owned by it; (vi) Steven A. Cohen with respect to Shares
               beneficially owned by SAC Capital Advisors, SAC Capital
               Management, SAC Capital Associates, SAC Healthco and SAC
               MultiQuant.

ITEM 2(B)      ADDRESS OF PRINCIPAL BUSINESS OFFICE:

               The address of the principal business office of (i) SAC
               Capital Advisors and Mr. Cohen is 72 Cummings Point Road,
               Stamford, Connecticut 06902, (ii) SAC Capital Management is
               540 Madison Avenue, New York, New York 10022, and (iii) SAC
               Capital Associates, SAC Healthco and SAC MultiQuant is P.O.
               Box 58, Victoria House, The Valley, Anguilla, British West
               Indies.

ITEM 2(C)      CITIZENSHIP:

               SAC Capital Advisors and SAC Capital Management are Delaware
               limited liability companies. SAC Capital Associates, SAC
               Healthco and SAC MultiQuant are Anguillan limited liability
               companies. Mr. Cohen is a United States citizen.


                                  Page 8 of 13





ITEM 2(D)     TITLE OF CLASS OF SECURITIES:

              Common Stock, par value $0.001 per share

ITEM 2(E)     CUSIP NUMBER:

              492515101

ITEM 3        Not Applicable

ITEM 4        OWNERSHIP:

              The percentages used herein are calculated based upon the
              Shares issued and outstanding as of November 5, 2004 as
              reported on the Company's quarterly report on Form 10-Q filed
              with the Securities and Exchange Commission by the Issuer for
              the quarterly period ended September 30, 2004.

              As of the close of business on December 31,
2004:

              1. S.A.C. Capital Advisors, LLC 
              (a) Amount beneficially owned: 1,821,506* 
              (b) Percent of class: 5.6% 
              (c)(i) Sole power to vote or direct the vote: -0- 
              (ii) Shared power to vote or direct the vote: 1,821,506* 
              (iii) Sole power to dispose or direct the disposition: -0-
              (iv) Shared power to dispose or direct the disposition: 1,821,506*

              2. S.A.C. Capital Management, LLC (a) Amount
              beneficially owned: 1,821,506* (b) Percent
              of class: 5.6% (c)(i) Sole power to vote or
              direct the vote: -0- (ii) Shared power to
              vote or direct the vote: 1,821,506* (iii)
              Sole power to dispose or direct the
              disposition: -0-
              (iv) Shared power to dispose or direct the
              disposition: 1,821,506*




                                  Page 9 of 13





              3. S.A.C. Capital Associates, LLC 
              (a) Amount beneficially owned: 1,245,000 
              (b) Percent of class: 4.0% 
              (c)(i) Sole power to vote or direct the vote: -0- 
              (ii) Shared power to vote or direct the vote: 1,245,000 
              (iii) Sole power to dispose or direct the disposition: -0-
              (iv) Shared power to dispose or direct the disposition: 1,245,000

              4. S.A.C. Healthco Fund, LLC 
              (a) Amount beneficially owned: 514,588* 
              (b) Percent of class: 1.6% 
              (c)(i) Sole power to vote or direct the vote: -0- 
              (ii) Shared power to vote or direct the vote: 514,588* 
              (iii) Sole power to dispose or direct the disposition: -0-
              (iv) Shared power to dispose or direct the disposition: 514,588*

              5. S.A.C. MultiQuant Fund, LLC 
              (a) Amount beneficially owned: 61,800 
              (b) Percent of class: Less than 0.2% 
              (c)(i) Sole power to vote or direct the vote: -0- 
              (ii) Shared power to vote or direct the vote: 61,800
              (iii) Sole power to dispose or direct the disposition: -0-
              (iv) Shared power to dispose or direct the disposition: 61,800

              6. Steven A. Cohen
              (a) Amount beneficially owned: 1,821,506*
              (b) Percent of class: 5.6% 
              (c)(i) Sole power to vote or direct the vote: -0- 
              (ii) Shared power to vote or direct the vote: 1,821,506*
              (iii) Sole power to dispose or direct the disposition: -0-
              (iv) Shared power to dispose or direct the disposition: 1,821,506*

              *The number of shares reported herein includes 94,118 shares
              issuable upon exercise warrants held by SAC Healthco.

              SAC Capital Advisors, SAC Capital Management, and Mr. Cohen
              own directly no shares of Common Stock. Pursuant to investment
              agreements, each of SAC Capital Advisors and SAC Capital
              Management share all investment and voting power with respect
              to the securities held by SAC Capital Associates, SAC Healthco
              and SAC MultiQuant. Mr. Cohen controls each of SAC Capital
              Advisors and SAC Capital Management. By reason of the
              provisions of Rule 13d-3 of the Securities Exchange Act of
              1934, as amended, each of SAC Capital Advisors, SAC Capital
              Management and Mr. Cohen may be deemed to own beneficially
              1,821,506 Shares (constituting approximately 5.6% of the
              Shares outstanding). Each of SAC Capital Advisors, SAC Capital
              Management, and Mr. Cohen disclaim beneficial ownership of any
              of the securities covered by this statement.

                                 Page 10 of 13



ITEM 5         OWNERSHIP OF FIVE PERCENT OR LESS OF A CLASS:
               -------------------------------------------- 

               If this statement is being filed to report the fact that as of
               the date hereof the reporting person has ceased to be the
               beneficial owner of more than five percent of the class of
               securities, check the following.

ITEM 6         OWNERSHIP OF MORE THAN FIVE PERCENT ON BEHALF OF ANOTHER PERSON:
               --------------------------------------------------------------- 

               Not Applicable

ITEM 7         IDENTIFICATION AND CLASSIFICATION OF THE
               SUBSIDIARY WHICH ACQUIRED THE SECURITY BEING
               REPORTED ON BY THE PARENT HOLDING COMPANY:
               ----------------------------------------- 

               Not Applicable

ITEM 8         IDENTIFICATION AND CLASSIFICATION OF MEMBERS 
               OF THE GROUP:
               ---------------------------------------------

               Not Applicable

ITEM 9         NOTICE OF DISSOLUTION OF GROUP:
               ------------------------------ 

               Not Applicable

ITEM 10                    CERTIFICATION:

         By signing below the signatory certifies that, to the best of his
knowledge and belief, the securities referred to above were not acquired and are
not held for the purpose of or with the effect of changing or influencing the
control of the issuer of the securities and were not acquired and are not held
in connection with or as a participant in any transaction having that purpose or
effect.


                                 Page 11 of 13




                                    SIGNATURE


         After reasonable inquiry and to the best of my knowledge and belief, I
certify that the information set forth in this statement is true, complete and
correct.


Dated:  February 14, 2005


S.A.C. CAPITAL ADVISORS, LLC


By: /s/ Peter Nussbaum
   -----------------------------------------
Name:  Peter Nussbaum
Title:  Authorized Person


S.A.C. CAPITAL MANAGEMENT, LLC


By: /s/ Peter Nussbaum
   -----------------------------------------
Name:  Peter Nussbaum
Title:  Authorized Person


S.A.C. CAPITAL ASSOCIATES, LLC


By: /s/ Peter Nussbaum
   -----------------------------------------
Name:  Peter Nussbaum
Title:  Authorized Person


S.A.C. HEALTHCO FUND, LLC


By: /s/ Peter Nussbaum
   -----------------------------------------
Name:  Peter Nussbaum
Title:  Authorized Person



                                 Page 12 of 13





S.A.C. MULTIQUANT FUND, LLC


By: /s/ Peter Nussbaum
   -----------------------------------------
Name:  Peter Nussbaum
Title:  Authorized Person


STEVEN A. COHEN


By: /s/ Peter Nussbaum
   -----------------------------------------
Name:  Peter Nussbaum
Title:  Authorized Person

                                 Page 13 of 13