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*** Exercise Your Right to Vote ***  Important Notice Regarding the Availability of Proxy Materials for the  Stockholder Meeting to Be Held on May 23, 2019.  Meeting Information  AIMMUNE THERAPEUTICS, INC.  Meeting Type: Annual Meeting  For holders as of: March 29, 2019  Date: May 23, 2019 Time: 9:00 AM, Pacific Time  Location:  8000 Marina Boulevard, Suite 300  Brisbane, CA 94005    You are receiving this communication because you hold shares in the company named above.   This is not a ballot. You cannot use this notice to vote these shares. This communication presents only an overview of the more complete proxy materials that are available to you on the Internet. You may view the proxy materials online at or easily request a paper copy (see reverse side).   We encourage you to access and review all of the important information contained in the proxy materials before voting.  AIMMUNE THERAPEUTICS, INC.  8000 MARINA BLVD.  SUITE 300   BRISBANE, CA 94005  E71349-P22667  See the reverse side of this notice to obtain proxy materials and voting instructions.



Before You Vote    How to Access the Proxy Materials    Proxy Materials Available to VIEW or RECEIVE:    NOTICE AND PROXY STATEMENT FORM 10-K    How to View Online:    Have the information that is printed in the box marked by the arrow (located on the   following page) and visit:    How to Request and Receive a PAPER or E-MAIL Copy:    If you want to receive a paper or e-mail copy of these documents, you must request one. There is NO charge for   requesting a copy. Please choose one of the following methods to make your request:          1) BY INTERNET:     2) BY TELEPHONE: 1-800-579-1639     3) BY E-MAIL*:    * If requesting materials by e-mail, please send a blank e-mail with the information that is printed in the box marked   by the arrow (located on the following page) in the subject line.    .    XXXX XXXX XXXX XXXX    .    XXXX XXXX XXXX XXXX    Requests, instructions and other inquiries sent to this e-mail address will NOT be forwarded to your investment   advisor. Please make the request as instructed above on or before May 9, 2019 to facilitate timely delivery.    How To Vote    E71350-P22667    Please Choose One of the Following Voting Methods    Vote In Person: Please see the Notice and Proxy Statement for complete information regarding meeting attendance.   At the meeting, you will need to request a ballot to vote these shares.     Vote By Internet: To vote now by Internet, go to Have the information that is printed in the box  marked by the arrow (located on the following page) available and follow the instructions.         Vote By Mail: You can vote by mail by requesting a paper copy of the materials, which will include a proxy card.



Voting Items      The Board of Directors recommends you vote FOR the following:      1. Election of Directors to hold office until the Company's 2022 annual meeting of stockholders.       Nominees:       01) Jayson D.A. Dallas, M.D.       02) Mark T. Iwicki       03) Gregory Behar      The Board of Directors recommends you vote FOR the following proposals:      2. To ratify the selection, by the Audit Committee of the Company’s Board of Directors, of KPMG LLP as the independent registered    public accounting firm of the Company for its fiscal year ending December 31, 2019.      3. To approve the compensation of the named executive officers as disclosed in the Company's proxy statement in accordance with the    compensation disclosure rules of the Securities and Exchange Commission.      In their discretion, the proxies are authorized to vote upon such other business as may properly come before the Annual Meeting.