Examples of major mechanisms causing cardiotoxicity of anticancer treatmentsCreative Animodel today announced that its innovative biological products and services department—preclinical services, has introduced a series of Cardiotoxicity Services to market.
Creative Animodel today announced that its innovative biological products and services department—preclinical services, has introduced a series of Cardiotoxicity Services to market.
According to Wikipedia description, cardiotoxicity is the occurrence of heart electrophysiology dysfunction or muscle damage, which makes heart turning weaker and is not as efficient in pumping circulating blood. To be more briefly, cardiotoxicity is “toxicity that impacts heart”. It may be drived from chemotherapy treatment, complications from anorexia nervosa, adverse effects of heavy metals intake, or an incorrectly administered drug such as bupivacaine.
One of the ways to detect cardiotoxicity at early stages when there is a subconical dysfunction is by measuring changes in regional function of the heart using strain. In terms of preclinical researches, cardiotoxicity is usually used in drug discovery or candidate drugs screening.
Compared with other preclinical drug discovery and cardiotoxicity screens, Creative Animodel’s Preclinical cardiotoxicity screening has the following features:
Professional assay platforms to offer reliable data
Human pluripotent stem cell-derived cardiomyocytes available
Diverse approaches to detect and characterize cardiac safely risks
Assays conducted according to regulatory guidance
This service enables more accurately cardiotoxicity predict. These derived cell types are available as ready-to-order assays, application-specific or custom services based on novice and expert users.
"According to numerous data, many drug candidate failures in clinical trials are often caused by cardiac safety issues. If there is a simple and easier way to early identification of these cardiac liabilities, much lose can be saved. However, such early identification is limited by the lack of reliable and standardized cardiomyocyte cell culture models," said Joseon Miller, Market Segment Manager of at Creative Animodel.
"Making efforts to avoid clinical trial failures is a principle drive force for Creative Animodel. We make commitment to alleviate critical deficiencies in ADME/Toxicology screening and preclinical development through our experienced scientists and automation platforms."
Available Cardiotoxicity Services at Creative Animodel:
Microelectrode Array
Cardiotoxicity Assays
hERG Inhibition
Cardiac Channels
Action Potential Duration
QT Prolongation Assay
Arrhythmogenic Liability Screening Comprehensive in Vitro Proarrhythmia Assay (CiPA)
3D Cardiotoxicity Assay
About Creative Animodel
With years of experience, Creative Animodel offers a wide range of toxicology and safety pharmacology assays for the early stage of drug discovery and development. The company’s cardiotoxicity services provide clients high-quality data to detect cardiac risk and support drug discovery in a cost-effective and time-saving manner. Its disease animal models and test assays are used in scientific and genomic research, biotechnology and pharmaceutical development. Creative Animodel has clients in life science companies, university and government institutions, hospitals, and in industry.
Media Contact
Company Name: Creative Animodel
Contact Person: Anna Shirley
Email: Send Email
Phone: 6316197922
Address:45-1 Ramsey Road
City: Shirley
State: New York
Country: United States
Website: https://www.creative-animodel.com
Source: www.abnewswire.com
