SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549
                                    ________

                                    FORM 6-K

                        REPORT OF FOREIGN PRIVATE ISSUER
                      PURSUANT TO RULE 13A-16 OR 15D-16 OF
                       THE SECURITIES EXCHANGE ACT OF 1934

                          For the month of March, 2003

                                   Serono S.A.
                    ----------------------------------------
                               (Registrant's Name)

                            15 bis, Chemin des Mines
                                 Case Postale 54
                                CH-1211 Geneva 20
                                   Switzerland
                    ----------------------------------------
                    (Address of Principal Executive Offices)

                                    1-15096
                    ----------------------------------------
                              (Commission File No.)

     (Indicate  by  check  mark whether the registrant files or will file annual
reports  under  cover  of  Form  20-F  or  Form  40-F.)

     Form  20-F  X    Form  40-F
                ---              ---

     (Indicate  by  check  mark  if the registrant is submitting the Form 6-K in
paper  as  permitted  by  Regulation  S-T  Rule  101  (b)(1).)  ______

     (Indicate  by  check  mark  if the registrant is submitting the Form 6-K in
paper  as  permitted  by  Regulation  S-T  Rule  101  (b)(7).)  ______

     (Indicate  by  check  mark  whether  the  registrant  by  furnishing  the
information contained in this form is also thereby furnishing the information to
the  Commission  pursuant to Rule 12g3-2(b) under the Securities Exchange Act of
1934.)

     Yes      No  X
         ---     ---

     (If  "Yes"  is  marked,  indicate  below  the  file  number assigned to the
registrant  in  connection  with  Rule  12g3-2(b):  82-______)



                                                                          SERONO



MEDIA  RELEASE


FOR  IMMEDIATE  RELEASE
-----------------------


               SERONO ANNOUNCES NEW SENIOR MANAGEMENT APPOINTMENTS


GENEVA,  SWITZERLAND,  AND  ROCKLAND,  MA,  USA  -MARCH  25,  2003  -
SERONO  S.A.  (VIRT-X:  SEO  AND  NYSE:  SRA).
As  part  of  its  succession planning, Serono today announced senior management
appointments  following  the  retirement  of  two executives after many years of
service  with  the  company.

Serono  announced  the  appointment  of  Fereydoun Firouz as President of its US
operations,  Serono,  Inc.  Mr.  Firouz  is  currently Executive Vice President,
Reproductive  Health,  Serono,  Inc.  He  replaces  Jean-Pierre Verhassel who is
retiring  from  operational  responsibilities  after  more than fifteen years of
service  to  Serono in various senior management positions. However, the company
will  continue  to  benefit from Mr. Verhassel's experience in his non-executive
role  as  Chairman  of  Serono,  Inc.

In  addition,  Serono  announced  the appointment of Dr. Timothy Wells as Senior
Executive  Vice  President  of  Research.  Dr. Wells will be responsible for the
company's  global discovery and early development operations. Dr. Wells has been
with  the  company  as  Head of Discovery since 1998 and he replaces Dr. Silvano
Fumero  who  is  retiring after a career with Serono that spanned over 30 years.

"These  appointments  are  part  of  our succession planning at Serono, and will
ensure the continued development of the company," said Ernesto Bertarelli, Chief
Executive  Officer.  "Both  Fereydoun  and  Tim  have  a  strong track record of
leadership and will continue to make significant contributions to the success of
Serono,"  he  added.

Serono  also  announced  that  Dr.  Stevo  Knezevic  is  leaving to join another
company.  His  responsibilities  for clinical development will be assumed by Dr.
Franck  Latrille  in  a  broader role as Senior Executive Vice President, Global
Product  Development.


BACKGROUND  ON  NEW  APPOINTEES
Most  recently,  Fereydoun Firouz has held the role of Executive Vice President,
Reproductive  Health, of Serono, Inc.  Prior to his appointment to that position
in 2001, Mr. Firouz worked in positions of increasing responsibility in Serono's
sales  and



marketing  operations  since  1991  and in Serono's government affairs office in
Washington,  D.C.  from  1989  to 1991. Mr. Firouz holds a BS degree from George
Washington  University  and  participated  in  the  executive program in general
management  at  Babson  College.

Since  1998  Tim  Wells  has served as Serono's Vice President Research, Head of
Discovery. From 1990 until he joined Serono in 1998, Dr. Wells held positions of
increasing  responsibility  in research at Glaxo Wellcome. Dr. Wells holds a PhD
degree  in  the chemistry of enzyme action and protein engineering from Imperial
College, London, and a bachelor's degree in natural sciences from the University
of  Cambridge.

Franck Latrille has been Serono's Senior Executive Vice President, Manufacturing
Operations  and  Process Development since 2003 and has held a variety of senior
management  positions  since  joining  Serono  in 1994.  He also has substantial
previous  biotechnology  experience.  Dr.  Latrille holds a PhD degree in animal
physiology  and  biochemistry  and an MS degree from the University of Bordeaux.


                                       ###

Some  of  the  statements  in  this  press  release  are  forward  looking. Such
statements  are inherently subject to known and unknown risks, uncertainties and
other  factors  that  may  cause  actual results, performance or achievements of
Serono  S.A.  and  affiliates  to be materially different from those expected or
anticipated  in  the  forward-looking statements. Forward-looking statements are
based on Serono's current expectations and assumptions, which may be affected by
a  number  of  factors, including those discussed in this press release and more
fully  described  in  Serono's  Annual  Report  on Form 20-F filed with the U.S.
Securities  and  Exchange  Commission  on May 21 2002. These factors include any
failure  or  delay  in  Serono's ability to develop new products, any failure to
receive  anticipated  regulatory  approvals,  any  problems  in  commercializing
current  products  as  a  result of competition or other factors, our ability to
obtain  reimbursement  coverage  for  our  products,  and government regulations
limiting  our  ability  to  sell  our  products. Serono has no responsibility to
update the forward-looking statements contained in this press release to reflect
events  or  circumstances  occurring  after  the  date  of  this  press release.


                                       ###


ABOUT  SERONO
Serono  is  a  global  biotechnology  leader.  The  Company  has six recombinant
products  on  the worldwide market, Gonal-F(R) (follitropin alfa for injection),
Luveris(R)  (lutropin  alfa),  (Luveris(R)  is  not  approved  in  the  USA.),
Ovidrel(R)/Ovitrelle(R)  (choriogonadotropin  alfa  for  injection),  Rebif(R)
(interferon  beta-1a),  Serostim(R) [somatropin (rDNA origin) for injection] and
Saizen(R)  [somatropin  (rDNA  origin)  for injection]. In addition to being the
world  leader  in  reproductive  health,  Serono  has strong market positions in
neurology, metabolism and growth. The Company's research programs are focused on
growing  these  businesses and on establishing new therapeutic areas. Currently,
there  are  over  30  projects  in  development.

Serono  was  awarded the International James D. Watson Helix 2003 Award from the
Biotechnology  Industry  Organization  (BIO)  in  recognition  of  the Company's
outstanding  leadership  and  highest  standards  of  scientific  and  product
achievement.

In  2002,  Serono  achieved  worldwide  revenues  of US$1.546 billion, and a net
income  of  US$321  million,  making it the third largest biotech company in the
world.  The  Company  operates  in  45  countries,  and  its



products  are  sold  in  over  100  countries. Bearer shares of Serono S.A., the
holding  company,  are  traded  on  the virt-x (SEO) and its American Depositary
Shares  are  traded  on  the  New  York  Stock  Exchange  (SRA).



FOR MORE INFORMATION, PLEASE CONTACT:

SERONO IN GENEVA, SWITZERLAND:
MEDIA  RELATIONS:                  INVESTOR  RELATIONS:
Tel:  +41-22-739 36 00             Tel:  +41-22-739 36 01
Fax:  +41-22-739 30 85             Fax:  +41-22-739 30 22
http://www.serono.com              Reuters:  SEOZ.VX / SRA.N
---------------------              Bloomberg:  SEO VX / SRA US
SERONO, INC., ROCKLAND, MA
MEDIA  RELATIONS:                  INVESTOR  RELATIONS:
Tel.  +1 781 681 2340              Tel.  +1 781 681 2552
Fax:  +1 781 681 2935              Fax:  +1 781 681 2912
http://www.seronousa.com
------------------------


                                      -end-



                                   SIGNATURES

     Pursuant  to  the  requirements of the Securities Exchange Act of 1934, the
registrant  has  duly  caused  this  report  to  be  signed on its behalf by the
undersigned,  thereunto  duly  authorized.


                                          SERONO  S.A.
                                          a  Swiss  corporation
                                          (Registrant)


March 26, 2003                      By:   /s/  Allan Shaw
                                          -------------------------------
                                          Name:   Allan  Shaw
                                          Title:  Chief Financial Officer