Ownership Submission
FORM 4
Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940
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(Print or Type Responses)
1. Name and Address of Reporting Person *
Lamb Peter
  2. Issuer Name and Ticker or Trading Symbol
EXELIXIS INC [EXEL]
5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
_____ Director _____ 10% Owner
__X__ Officer (give title below) _____ Other (specify below)
SVP, Discovery Research & CSO
(Last)
(First)
(Middle)
C/O EXELIXIS, INC., 249 EAST GRAND AVE., PO BOX 511
3. Date of Earliest Transaction (Month/Day/Year)
08/04/2009
(Street)

SOUTH SAN FRANCISCO, CA 94083-0511
4. If Amendment, Date Original Filed(Month/Day/Year)
6. Individual or Joint/Group Filing(Check Applicable Line)
_X_ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person
(City)
(State)
(Zip)
Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security
(Instr. 3)
2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code
(Instr. 8)
4. Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)
5. Amount of Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 3 and 4)
6. Ownership Form: Direct (D) or Indirect (I)
(Instr. 4)
7. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V Amount (A) or (D) Price

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
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Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
(Instr. 3)
2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (Month/Day/Year) 3A. Deemed Execution Date, if any (Month/Day/Year) 4. Transaction Code
(Instr. 8)
5. Number of Derivative Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4, and 5)
6. Date Exercisable and Expiration Date
(Month/Day/Year)
7. Title and Amount of Underlying Securities
(Instr. 3 and 4)
8. Price of Derivative Security
(Instr. 5)
9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 4)
10. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 4)
11. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares
Option (right to buy) $ 7.47 08/04/2009   D     25,000 04/15/2004(1) 04/14/2013 Common Stock 25,000 (2) 0 D  
Option (right to buy) $ 5.63 08/05/2009   A   20,000   08/05/2010(3) 10/17/2015 Common Stock 20,000 (2) 20,000 D  
Option (right to buy) $ 7.85 08/04/2009   D     10,000 12/20/2003(1) 12/19/2012 Common Stock 10,000 (4) 0 D  
Option (right to buy) $ 5.63 08/05/2009   A   8,000   08/05/2010(3) 10/17/2015 Common Stock 8,000 (4) 8,000 D  
Option (right to buy) $ 8.92 08/04/2009   D     35,000 12/13/2005(1) 12/12/2014 Common Stock 35,000 (5) 0 D  
Option (right to buy) $ 5.63 08/05/2009   A   28,000   08/05/2010(3) 10/17/2015 Common Stock 28,000 (5) 28,000 D  
Option (right to buy) $ 9 08/04/2009   D     1,750 01/15/2002(1) 01/14/2011 Common Stock 1,750 (6) 0 D  
Option (right to buy) $ 5.63 08/05/2009   A   1,400   08/05/2010(3) 10/17/2015 Common Stock 1,400 (6) 1,400 D  
Option (right to buy) $ 9 08/04/2009   D     80,000 01/02/2008(1) 01/01/2017 Common Stock 80,000 (8) 0 D  
Option (right to buy) $ 5.63 08/05/2009   A   39,999   08/05/2010(3) 10/17/2015 Common Stock 39,999 (8) 39,999 D  
Option (righ to buy) $ 5.63 08/05/2009   A   24,001   08/05/2010(7) 10/17/2015 Common Stock 24,001 (8) 24,001 D  
Option (right to buy) $ 9.42 08/04/2009   D     120,000 01/02/2007(1) 01/01/2016 Common Stock 120,000 (9) 0 D  
Option (right to buy) $ 5.63 08/05/2009   A   84,000   08/05/2010(3) 10/17/2015 Common Stock 84,000 (9) 84,000 D  
Option (right to buy) $ 5.63 08/05/2009   A   12,000   08/05/2010(7) 10/17/2015 Common Stock 12,000 (9) 12,000 D  
Option (right to buy) $ 9.85 08/04/2009   D     40,000 01/19/2008(1) 01/18/2017 Common Stock 40,000 (10) 0 D  
Option (right to buy) $ 5.63 08/05/2009   A   19,333   08/05/2010(3) 10/17/2015 Common Stock 19,333 (10) 19,333 D  
Option (right to buy) $ 5.63 08/05/2009   A   12,667   08/05/2010(7) 10/17/2015 Common Stock 12,667 (10) 12,667 D  
Option (right to buy) $ 9.91 08/04/2009   D     125,000 12/06/2008(1) 12/05/2017 Common Stock 125,000 (11) 0 D  
Option (right to buy) $ 5.63 08/05/2009   A   39,583   08/05/2010(3) 10/17/2015 Common Stock 39,583 (11) 39,583 D  
Option (right to buy) $ 5.63 08/05/2009   A   60,417   08/05/2010(7) 10/17/2015 Common Stock 60,417 (11) 60,417 D  
Option (right to buy) $ 16.62 08/04/2009   D     10,000 01/01/2003(1) 12/31/2011 Common Stock 10,000 (12) 0 D  
Option (right to buy) $ 5.63 08/05/2009   A   2,500   08/05/2010(3) 10/17/2015 Common Stock 2,500 (12) 2,500 D  
Option (right to buy) $ 20.125 08/04/2009   D     47,250 10/15/2001(1) 10/31/2010 Common Stock 47,250 (13) 0 D  
Option (right to buy) $ 5.63 08/05/2009   A   525   08/05/2010(3) 10/17/2015 Common Stock 525 (13) 525 D  

Reporting Owners

Reporting Owner Name / Address Relationships
 Director  10% Owner  Officer  Other
Lamb Peter
C/O EXELIXIS, INC.
249 EAST GRAND AVE., PO BOX 511
SOUTH SAN FRANCISCO, CA 94083-0511
      SVP, Discovery Research & CSO  

Signatures

 /s/ James B. Bucher, Attorney in Fact   08/06/2009
**Signature of Reporting Person Date

Explanation of Responses:

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1) The option provided for vesting as follows: twenty five percent (25%) of the shares one year from date of grant, and the remaining shares in 36 equal monthly installments thereafter.
(2) On August 4, 2009, the Issuer cancelled, pursuant to the Issuer's option exchange program, an option for 25,000 shares of the Issuer's common stock granted to the reporting person on April 15, 2003. In exchange, on August 5, 2009, the reporting person received a replacement option for 20,000 shares of the Issuer's common stock, having an exercise price of $5.63.
(3) Option granted pursuant to Issuer's 2000 Equity Incentive Plan. One hundred percent (100%) of the shares vest one year from date of grant.
(4) On August 4, 2009, the Issuer cancelled, pursuant to the Issuer's option exchange program, an option for 10,000 shares of the Issuer's common stock granted to the reporting person on December 20, 2002. In exchange, on August 5, 2009, the reporting person received a replacement option for 8,000 shares of the Issuer's common stock, having an exercise price of $5.63.
(5) On August 4, 2009, the Issuer cancelled, pursuant to the Issuer's option exchange program, an option for 35,000 shares of the Issuer's common stock granted to the reporting person on December 13, 2004. In exchange, on August 5, 2009, the reporting person received a replacement option for 28,000 shares of the Issuer's common stock, having an exercise price of $5.63.
(6) On August 4, 2009, the Issuer cancelled, pursuant to the Issuer's option exchange program, an option for 1,750 shares of the Issuer's common stock granted to the reporting person on January 15, 2001. In exchange, on August 5, 2009, the reporting person received a replacement option for 1,400 shares of the Issuer's common stock, having an exercise price of $5.63.
(7) Option granted pursuant to Issuer's 2000 Equity Incentive Plan. Thirty-three percent (33%) of the shares vest one year from date of grant, and the remaining shares vest in 24 equal monthly installments thereafter.
(8) On August 4, 2009, the Issuer cancelled, pursuant to the Issuer's option exchange program, an option for 80,000 shares of the Issuer's common stock granted to the reporting person on January 2, 2007. In exchange, on August 5, 2009, the reporting person received two replacement options for 39,999 and 24,001 shares of the Issuer's common stock, respectively, each having an exercise price of $5.63.
(9) On August 4, 2009, the Issuer cancelled, pursuant to the Issuer's option exchange program, an option for 120,000 shares of the Issuer's common stock granted to the reporting person on January 2, 2006. In exchange, on August 5, 2009, the reporting person received two replacement options for 84,000 and 12,000 shares of the Issuer's common stock, respectively, each having an exercise price of $5.63.
(10) On August 4, 2009, the Issuer cancelled, pursuant to the Issuer's option exchange program, an option for 40,000 shares of the Issuer's common stock granted to the reporting person on January 19, 2007. In exchange, on August 5, 2009, the reporting person received two replacement options for 19,333 and 12,667 shares of the Issuer's common stock, respectively, each having an exercise price of $5.63.
(11) On August 4, 2009, the Issuer cancelled, pursuant to the Issuer's option exchange program, an option for 125,000 shares of the Issuer's common stock granted to the reporting person on December 6, 2007. In exchange, on August 5, 2009, the reporting person received two replacement options for 39,583 and 60,417 shares of the Issuer's common stock, respectively, each having an exercise price of $5.63.
(12) On August 4, 2009, the Issuer cancelled, pursuant to the Issuer's option exchange program, an option for 10,000 shares of the Issuer's common stock granted to the reporting person on January 1, 2002. In exchange, on August 5, 2009, the reporting person received a replacement option for 2,500 shares of the Issuer's common stock, having an exercise price of $5.63.
(13) On August 4, 2009, the Issuer cancelled, pursuant to the Issuer's option exchange program, an option for 47,250 shares of the Issuer's common stock granted to the reporting person on October 15, 2000. In exchange, on August 5, 2009, the reporting person received a replacement option for 525 shares of the Issuer's common stock, having an exercise price of $5.63.

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