SCHEDULE 13G

 

SECURITIES AND EXCHANGE COMMISSION
WASHINGTON, DC 20549


Under the Securities Exchange Act of 1934
(Amendment No. )*

 

Biocryst Pharmaceuticals, Inc.
	(Name of Issuer)
Common Stock, par value $0.01 per share
	(Title of Class of Securities)
	09058V103
	(CUSIP Number)
	February 25, 2014
	(Date of Event which Requires Filing of this Statement)

 

Check the appropriate box to designate the rule pursuant to which this Schedule is filed:

 

x Rule 13d-1(b)

 

¨ Rule 13d-1(c)

 

¨ Rule 13d-1(d)

 

*The remainder of this cover page shall be filled out for a reporting person’s initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter disclosures provided in a prior cover page.

 

The information required on the remainder of this cover page shall not be deemed to be “filed” for the purpose of Section 18 of the Securities Exchange Act of 1934 (the “Act”) or otherwise subject to the liabilities of that section of the Act, but shall be subject to all other provisions of the Act (however, see the Notes).

 

 

CUSIP No.  09058V103

 

1	NAMES OF REPORTING PERSONS I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (entities only)   Baker Bros. Advisors LP   13-4093645
2	CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (See Instructions) (a) ¨  (b) ¨
3	SEC USE ONLY
4	CITIZENSHIP OR PLACE OF ORGANIZATION   Delaware

NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH	5	SOLE VOTING POWER   6,699,979
	6	SHARED VOTING POWER   -0-
	7	SOLE DISPOSITIVE POWER   6,699,979
	8	SHARED DISPOSITIVE POWER   -0-

9	AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON   6,699,979
10	CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES                  ¨ (See Instructions)
11	PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9   11.3% (1)
12	TYPE OF REPORTING PERSON (See Instructions) IA, PN

 

(1)

Based on 59,091,393 shares of common stock outstanding as of October 31, 2013, as reported in the Issuer’s Form 10-Q filed with the SEC on November 8, 2013.

   

 

CUSIP No.  09058V103

 

1	NAMES OF REPORTING PERSONS I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (entities only)   Baker Bros. Advisors (GP) LLC   46-3147749
2	CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (See Instructions) (a) ¨  (b) ¨
3	SEC USE ONLY
4	CITIZENSHIP OR PLACE OF ORGANIZATION   Delaware

NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH	5	SOLE VOTING POWER   6,699,979
	6	SHARED VOTING POWER   -0-
	7	SOLE DISPOSITIVE POWER   6,699,979
	8	SHARED DISPOSITIVE POWER   -0-

9	AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON   6,699,979
10	CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES                  ¨ (See Instructions)
11	PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9   11.3% (1)
12	TYPE OF REPORTING PERSON (See Instructions) HC, OO

 

(1)

Based on 59,091,393 shares of common stock outstanding as of October 31, 2013, as reported in the Issuer’s Form 10-Q filed with the SEC on November 8, 2013.

  

 

CUSIP No.  09058V103

 

1	NAMES OF REPORTING PERSONS I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (entities only)      Felix J. Baker
2	CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (See Instructions) (a) ¨  (b) ¨
3	SEC USE ONLY
4	CITIZENSHIP OR PLACE OF ORGANIZATION   United States

NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH	5	SOLE VOTING POWER   6,699,979
	6	SHARED VOTING POWER   -0-
	7	SOLE DISPOSITIVE POWER   6,699,979
	8	SHARED DISPOSITIVE POWER   -0-

9	AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON   6,699,979
10	CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES                 ¨ (See Instructions)
11	PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9   11.3% (1)
12	TYPE OF REPORTING PERSON (See Instructions) IN, HC

 

(1)

Based on 59,091,393 shares of common stock outstanding as of October 31, 2013, as reported in the Issuer’s Form 10-Q filed with the SEC on November 8, 2013.

  

 

CUSIP No.  09058V103

 

1	NAMES OF REPORTING PERSONS I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (entities only)   Julian C. Baker
2	CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (See Instructions) (a) ¨  (b) ¨
3	SEC USE ONLY
4	CITIZENSHIP OR PLACE OF ORGANIZATION   United States

NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH	5	SOLE VOTING POWER   6,699,979
	6	SHARED VOTING POWER   -0-
	7	SOLE DISPOSITIVE POWER   6,699,979
	8	SHARED DISPOSITIVE POWER   -0-

9	AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON   6,699,979
10	CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES                  ¨ (See Instructions)
11	PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9   11.3% (1)
12	TYPE OF REPORTING PERSON (See Instructions) IN, HC

  

(1)

Based on 59,091,393 shares of common stock outstanding as of October 31, 2013, as reported in the Issuer’s Form 10-Q filed with the SEC on November 8, 2013.

 

 

Schedule 13G

 

This Schedule 13G amends the previously filed Schedule 13D as amended filed by Baker Bros. Advisors LP (the “Adviser”), Baker Bros. Advisors (GP) LLC (the “Adviser GP”), Julian C. Baker and Felix J. Baker. Dr. Stephen R. Biggar, an employee of the Adviser, effective October 10, 2011 no longer serves on the Issuer’s Board of Directors (the “Board”). The Adviser no longer has representation on the Board and holds the shares in the ordinary course of business without the purpose or effect of influencing the control of the Issuer.

 

 

Item 1(a)	Name of Issuer:
	Biocryst Pharmaceuticals, Inc. (the “Issuer”)
Item 1(b)	Address of Issuer’s Principal Executive Offices:
	4505 Emperor Blvd., Ste. 200
	Durham, North Carolina 27703
Item 2(a)	Name of Person Filing:
This Schedule 13G is being filed jointly by the Adviser, the Adviser GP, Felix J. Baker and Julian C. Baker (collectively, the “Reporting Persons”).
Item 2(b)	Address of Principal Business Office or, if None, Residence:
	The business address of each of the Reporting Persons is:
	c/o Baker Bros. Advisors LP
	667 Madison Avenue, 21st Floor
	New York, NY 10065
	(212) 339-5690
Item 2(c)	Citizenship:
	The Adviser is a limited partnership organized under the laws of the State of Delaware.  The Adviser GP is a limited liability company organized under the laws of the State of Delaware. The citizenship of each of Julian C. Baker and Felix J. Baker is the United States of America.

 

 

Item 2(d)	Title of Class of Securities
	Common Stock, par value $0.01
Item 2(e)	CUSIP Number
	09058V103
Item 3.	If this statement is filed pursuant to §§240.13d-1(b) or (c), check whether the person filing is a:

 

(a) ¨ Broker or dealer registered under Section 15 of the Exchange Act.

 

(b) ¨ Bank as defined in section 3(a)(6) of the Exchange Act.

 

(c) ¨ Insurance company as defined in section 3(a)(19) of the Exchange Act.

 

(d) ¨ Investment company registered under section 8 of the Investment Company Act of 1940.

 

(e) x An investment adviser in accordance with Rule 13d-1(b)(1)(ii)(E).

 

(f) ¨ An employee benefit plan or endowment fund in accordance with Rule 13d-1(b)(1)(ii)(F).

 

(g) x A parent holding company or control person in accordance with Rule 13d-1(b)(1)(ii)(G).

 

(h) ¨ A savings association as defined in Section 3(b) of the Federal Deposit Insurance Act.

 

(i) ¨ A church plan that is excluded from the definition of an investment company under section 3(c)(14) of the Investment Company Act of 1940.

 

(j) ¨ Group, in accordance with Rule 13d-1(b)(1)(ii)(J).

 

Item 4.

Ownership.

 

Items 5 through 9 and 11 of each of the cover pages to this Schedule 13G are incorporated herein reference. Certain securities of the Issuer are directly held by each of Baker Brothers Life Sciences, L.P. (“Life Sciences”), 14159, L.P. (“14159”), Baker Tisch Investments, L.P. (“Baker Tisch”), Baker Bros. Investments, L.P. (“Bros I”), Baker Bros. Investments II, L.P. (“Bros II”) and 667, L.P. (“667”, and together with Life Sciences, 14159, Baker Tisch, Bros I and Bros II, the “Funds”).

 

 

		Number of				Percent of
		Shares of				Class
Name		Common Stock				Outstanding
Baker Bros. Investments, L.P.			34,046				0.1	%
Baker Bros. Investments II, L.P.			28,361				0.0	%
Baker Tisch Investments, L.P.			17,241				0.0	%
667, L.P.			1,642,513				2.8	%
Baker Brothers Life Sciences, L.P.			4,832,285				8.2	%
14159, L.P.			145,533				0.2	%
Total			6,699,979				11.3	%

 

Pursuant to the amended and restated management agreements, as amended, among the Adviser, the Funds and their respective general partners, the Adviser has complete and unlimited discretion and authority with respect to the Funds’ investments and voting power over investments.

 

The Adviser GP, Felix J. Baker and Julian C. Baker as principals of the Adviser GP, and the Adviser may be deemed to be beneficial owners of securities of the Issuer directly held by the Funds, and may be deemed to have the sole power to vote or direct the vote of and the power to dispose or direct the disposition of such securities.

 

The Reporting Persons disclaim beneficial ownership of the securities held by each of the Funds, and this Schedule 13G shall not be deemed an admission that the Reporting Persons are the beneficial owners of such securities for purposes of Section 13(d) or for any other purpose.

 

Item 5.

Ownership of Five Percent or Less of a Class.

 

If this statement is being filed to report the fact that as of the date hereof the reporting person has ceased to be the beneficial owner of more than five percent of the class of securities, check the following ¨. N/A

 

Item 6.	Ownership of More than Five Percent on Behalf of Another Person.
	The information in Item 4 is incorporated herein by reference.

  

Item 7.	Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on by the Parent Holding Company or Control Person.
	The information in Item 4 is incorporated herein by reference.

  

Item 8.	Identification and Classification of Members of the Group.
	N/A

 

 

Item 9.	Notice of Dissolution of Group.
	N/A

 

Item 10.

Certification.

 

By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were acquired and are held in the ordinary course of business and were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect.

 

 

SIGNATURE

 

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

 

February 25, 2014

 

	BAKER BROS. ADVISORS LP
	By:  Baker Bros. Advisors (GP) LLC, its general partner
	By:	/s/ Scott L. Lessing
		Name: Scott L. Lessing
		Title: President
	BAKER BROS. ADVISORS (GP) LLC
	By:	/s/ Scott L. Lessing
		Name: Scott L. Lessing
		Title: President
		/s/ Julian C. Baker
		Julian C. Baker
		/s/ Felix J. Baker
		Felix J. Baker