Ownership Submission
FORM 4
Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940
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(Print or Type Responses)
1. Name and Address of Reporting Person *
Boxer Capital, LLC
   2. Issuer Name and Ticker or Trading Symbol
Mirati Therapeutics, Inc. [MRTX] 		5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
_____ Director __X__ 10% Owner
_____ Officer (give title below) _____ Other (specify below)
(Last)
(First)
(Middle)
440 STEVENS AVE, SUITE 100, 		 3. Date of Earliest Transaction (Month/Day/Year)
09/16/2015
(Street)

SOLANA BEACH, CA 92075		 4. If Amendment, Date Original Filed(Month/Day/Year)
 6. Individual or Joint/Group Filing(Check Applicable Line)
___ Form filed by One Reporting Person
_X_ Form filed by More than One Reporting Person
(City)
(State)
(Zip)
Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security
(Instr. 3)		 2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code
(Instr. 8)		 4. Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)		 5. Amount of Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 3 and 4)		 6. Ownership Form: Direct (D) or Indirect (I)
(Instr. 4)		 7. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V Amount (A) or (D) Price
Common Stock 09/16/2015   P   22,500 A $ 45 2,023,232 D (1)  
Common Stock 09/16/2015   P   22,500 A $ 45 522,500 D (2)  
Common Stock               429,340 D (3)  

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Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
(Instr. 3)		 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (Month/Day/Year) 3A. Deemed Execution Date, if any (Month/Day/Year) 4. Transaction Code
(Instr. 8)		 5. Number of Derivative Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4, and 5)		 6. Date Exercisable and Expiration Date
(Month/Day/Year)		 7. Title and Amount of Underlying Securities
(Instr. 3 and 4)		 8. Price of Derivative Security
(Instr. 5)		 9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 4)		 10. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 4)		 11. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares
Warrant (right to purchase) $ 6.74 09/17/2015   S     1   (4) 04/04/2016 Common Stock 272,882 $ 10,167,583.32 0 D (1)  
Warrant (right to purchase) $ 6.74 09/17/2015   S     1   (4) 04/04/2016 Common Stock 40,874 $ 1,522,965.24 0 D (3)  

Reporting Owners

Reporting Owner Name / Address Relationships
 Director  10% Owner  Officer  Other
Boxer Capital, LLC
440 STEVENS AVE, SUITE 100
SOLANA BEACH, CA 92075		     X    
Boxer Asset Management Inc.
C/O CAY HOUSE P.O. BOX N-7776
E.P. TAYLOR DRIVE LYFORD CAY
NEW PROVIDENCE, C5 		     X    
LEWIS JOSEPH
C/O CAY HOUSE P.O. BOX N-7776 E.P.
TAYLOR DRIVE LYFORD CAY
NEW PROVIDENCE, C5 		     X    
Berkley Capital Management Ltd.
C/O CAY HOUSE P.O. BOX N-7776 E.P.
TAYLOR DRIVE LYFORD CAY
NEW PROVIDENCE, C5 		     X    
MVA Investors, LLC
440 STEVENS AVE, SUITE 100
SOLANA BEACH, CA 92075		     X    

Signatures

 Boxer Capital, LLC, By: /s/ Aaron Davis   09/18/2015
**Signature of Reporting Person Date
 Boxer Asset Management, Inc., By: /s/ Jefferson Voss   09/18/2015
**Signature of Reporting Person Date
 MVA Investors, LLC, By: /s/ Aaron Davis   09/18/2015
**Signature of Reporting Person Date
 Joe Lewis, By: /s/ Joe Lewis   09/18/2015
**Signature of Reporting Person Date
 Berkley Capital Management Ltd., By: /s/ Jefferson Voss   09/18/2015
**Signature of Reporting Person Date

Explanation of Responses:

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1) These securities are owned directly by Boxer Capital, LLC ("Boxer Capital"), which may be deemed to be a member of a "group" for purposes of Section 13(d) of the Securities Exchange Act of 1934, as amended, consisting of (i) Boxer Capital, (ii) Boxer Asset Management Inc. ("Boxer Management"), (iii) MVA Investors, LLC ("MVA Investors"), (iv) Berkley Capital Management Ltd. ("Berkley Capital"), and (v) Joe Lewis (collectively, the "Boxer Group"), and indirectly by Boxer Management and Joe Lewis, by virtue of their ownership in Boxer Capital.
(2) These securities are owned directly by Berkley Capital, and indirectly by Joe Lewis. Joe Lewis is the sole indirect owner of and controls Berkley Capital.
(3) These securities are owned directly and solely by MVA Investors, which has sole voting and dispositive power with respect to these securities. Each member of the Boxer Group other than MVA Investors disclaims beneficial ownership of these securities to the extent it or he does not have a pecuniary interest therein.
(4) The warrants are not exercisable to the extent that, following exercise of such warrants, the warrant holder would hold more than 19.9% of the issuer's common stock.

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