UNITED
STATES
SECURITIES
AND EXCHANGE COMMISSION
Washington,
D.C. 20549
|
OMB
APPROVAL
OMB
Number: 3235-0145
Expires:
February 28, 2009
Estimated
average burden
hours
per response 14.5
|
Warren
T. Lazarow, Esq.
|
Paul
S. Scrivano, Esq.
|
O’Melveny
& Myers LLP
|
O’Melveny
& Myers LLP
|
2765
Sand Hill Road
|
Times
Square Tower
|
Menlo
Park, CA 94025
|
7
Times Square
|
(650)
473-2600
|
New
York, NY 10036
|
(212)
326-2000
|
|
1.
|
Names
of Reporting Persons
|
|
Palo
Alto Investors, Inc.
|
|
2.
|
Check
the Appropriate Box if a Member of a Group (See
Instructions)
|
|
(a)
|
|
(b)
|
X
|
|
3.
|
SEC
Use Only
|
|
4.
|
Source
of Funds (See Instructions)
|
AF
|
|
5.
|
Check
if Disclosure of Legal Proceedings Is Required Pursuant to Items 2(d) or
2(e) ____
|
|
6.
|
Citizenship
or Place of Organization
|
California
|
Number
of
Shares
Beneficially
Owned
by
Each
Reporting
Person
With
|
7. Sole
Voting
Power 0
|
8. Shared
Voting
Power 4,133,944
|
|
9. Sole
Dispositive
Power 0
|
|
10. Shared
Dispositive
Power 4,133,944
|
|
11.
|
Aggregate
Amount Beneficially Owned by Each Reporting Person4,133,944
|
|
12.
|
Check
if the Aggregate Amount in Row (11) Excludes Certain Shares
(See
|
|
Instructions)
|
|
13.
|
Percent
of Class Represented by Amount in Row (11)
|
8.3%
|
|
14.
|
Type
of Reporting Person (See Instructions)
|
CO,
HC
|
|
1.
|
Names
of Reporting Persons
|
|
Palo
Alto Investors, LLC
|
|
2.
|
Check
the Appropriate Box if a Member of a Group (See
Instructions)
|
|
(a)
|
|
(b)
|
X
|
|
3.
|
SEC
Use Only
|
|
4.
|
Source
of Funds (See Instructions)
|
AF
|
|
5.
|
Check
if Disclosure of Legal Proceedings Is Required Pursuant to Items 2(d) or
2(e) ____
|
|
6.
|
Citizenship
or Place of Organization
|
California
|
Number
of
Shares
Beneficially
Owned
by
Each
Reporting
Person
With
|
7. Sole
Voting
Power 0
|
8. Shared
Voting
Power 4,133,944
|
|
9. Sole
Dispositive
Power 0
|
|
10. Shared
Dispositive
Power 4,133,944
|
|
11.
|
Aggregate
Amount Beneficially Owned by Each Reporting Person4,133,944
|
|
12.
|
Check
if the Aggregate Amount in Row (11) Excludes Certain Shares
(See
|
|
Instructions)
|
|
13.
|
Percent
of Class Represented by Amount in Row (11)
|
8.3%
|
|
14.
|
Type
of Reporting Person (See Instructions)
|
IA,
OO
|
|
1.
|
Names
of Reporting Persons
|
|
William
Leland Edwards
|
|
2.
|
Check
the Appropriate Box if a Member of a Group (See
Instructions)
|
|
(a)
|
|
(b)
|
X
|
|
3.
|
SEC
Use Only
|
|
4.
|
Source
of Funds (See Instructions)
|
AF
|
|
5.
|
Check
if Disclosure of Legal Proceedings Is Required Pursuant to Items 2(d) or
2(e) ____
|
|
6.
|
Citizenship
or Place of Organization
|
____U.S.A.___
|
Number
of
Shares
Beneficially
Owned
by
Each
Reporting
Person
With
|
7. Sole
Voting
Power 28,000
|
8. Shared
Voting
Power 4,133,944
|
|
9. Sole
Dispositive
Power 28,000
|
|
10. Shared
Dispositive
Power 4,133,944
|
|
11.
|
Aggregate
Amount Beneficially Owned by Each Reporting Person4,161,944
|
|
12.
|
Check
if the Aggregate Amount in Row (11) Excludes Certain Shares
(See
|
|
Instructions)______
|
|
13.
|
Percent
of Class Represented by Amount in Row (11)
|
8.3%
|
|
14.
|
Type
of Reporting Person (See Instructions)
|
IN,
HC
|
|
1.
|
Names
of Reporting Persons
|
|
Anthony
Joonkyoo Yun, MD
|
|
2.
|
Check
the Appropriate Box if a Member of a Group (See
Instructions)
|
|
(a)
|
|
(b)
|
X
|
|
3.
|
SEC
Use Only
|
|
4.
|
Source
of Funds (See Instructions)
|
AF
|
|
5.
|
Check
if Disclosure of Legal Proceedings Is Required Pursuant to Items 2(d) or
2(e) ____
|
|
6.
|
Citizenship
or Place of Organization
|
U.S.A.
|
Number
of
Shares
Beneficially
Owned
by
Each
Reporting
Person
With
|
7. Sole
Voting
Power 0
|
8. Shared
Voting
Power 4,133,944
|
|
9. Sole
Dispositive
Power 0
|
|
10. Shared
Dispositive
Power 4,133,944
|
|
11.
|
Aggregate
Amount Beneficially Owned by Each Reporting Person4,133,944
|
|
12.
|
Check
if the Aggregate Amount in Row (11) Excludes Certain Shares
(See
|
|
Instructions)
|
|
13.
|
Percent
of Class Represented by Amount in Row (11)
|
8.3%
|
|
14.
|
Type
of Reporting Person (See Instructions)
|
IN,
HC
|
|
1.
|
Names
of Reporting Persons
|
|
Palo
Alto Small Cap Master Fund, L.P.
|
|
2.
|
Check
the Appropriate Box if a Member of a Group (See
Instructions)
|
|
(a)
|
|
(b)
|
X
|
|
3.
|
SEC
Use Only
|
|
4.
|
Source
of Funds (See Instructions)
|
AF
|
|
5.
|
Check
if Disclosure of Legal Proceedings Is Required Pursuant to Items 2(d) or
2(e) ____
|
|
6.
|
Citizenship
or Place of Organization
|
Cayman
Islands
|
Number
of
Shares
Beneficially
Owned
by
Each
Reporting
Person
With
|
7. Sole
Voting
Power 0
|
8. Shared
Voting
Power 2,881,972
|
|
9. Sole
Dispositive
Power 0
|
|
10. Shared
Dispositive
Power 2,881,972
|
|
11.
|
Aggregate
Amount Beneficially Owned by Each Reporting Person2,881,972
|
|
12.
|
Check
if the Aggregate Amount in Row (11) Excludes Certain Shares
(See
|
|
Instructions)
|
|
13.
|
Percent
of Class Represented by Amount in Row (11)
|
5.8%
|
|
14.
|
Type
of Reporting Person (See Instructions)
|
PN
|
|
1.
|
Names
of Reporting Persons
|
|
Palo
Alto Small Cap Fund, L.P.
|
|
2.
|
Check
the Appropriate Box if a Member of a Group (See
Instructions)
|
|
(a)
|
|
(b)
|
X
|
|
3.
|
SEC
Use Only
|
|
4.
|
Source
of Funds (See Instructions)
|
AF
|
|
5.
|
Check
if Disclosure of Legal Proceedings Is Required Pursuant to Items 2(d) or
2(e) ____
|
|
6.
|
Citizenship
or Place of Organization
|
Delaware
|
Number
of
Shares
Beneficially
Owned
by
Each
Reporting
Person
With
|
7. Sole
Voting
Power 0
|
8. Shared
Voting
Power 2,549,104
|
|
9. Sole
Dispositive
Power 0
|
|
10. Shared
Dispositive
Power 2,549,104
|
|
11.
|
Aggregate
Amount Beneficially Owned by Each Reporting Person2,549,104
|
|
12.
|
Check
if the Aggregate Amount in Row (11) Excludes Certain Shares
(See
|
|
Instructions)
|
|
13.
|
Percent
of Class Represented by Amount in Row (11)
|
5.1%
|
|
14.
|
Type
of Reporting Person (See Instructions)
|
PN
|
Filer
|
Date
|
Transaction
|
Purchased or Sold
|
Average Price Per Share
|
||||||
PAI,
LLC
|
4/12/2010
|
Sale
|
28,000 | $ | 5.27 | |||||
PAI,
LLC
|
4/15/2010
|
Sale
|
4,100 | $ | 5.38 | |||||
PAI,
LLC
|
4/16/2010
|
Sale
|
2,700 | $ | 5.32 | |||||
PAI,
LLC
|
4/19/2010
|
Sale
|
200 | $ | 5.28 | |||||
PAI,
LLC
|
4/20/2010
|
Sale
|
6,300 | $ | 5.24 | |||||
PAI,
LLC
|
4/21/2010
|
Sale
|
1,700 | $ | 5.23 | |||||
PAI,
LLC
|
4/22/2010
|
Sale
|
1,500 | $ | 5.23 | |||||
PAI,
LLC
|
4/23/2010
|
Sale
|
5,900 | $ | 5.28 | |||||
PAI,
LLC
|
4/26/2010
|
Sale
|
6,100 | $ | 5.51 | |||||
PAI,
LLC
|
4/27/2010
|
Sale
|
69,900 | $ | 5.25 | |||||
PAI,
LLC
|
4/28/2010
|
Sale
|
2,200 | $ | 5.35 | |||||
PAI,
LLC
|
4/29/2010
|
Sale
|
2,000 | $ | 5.32 | |||||
PAI,
LLC
|
4/30/2010
|
Sale
|
3,200 | $ | 5.26 | |||||
PAI,
LLC
|
5/3/2010
|
Sale
|
3,300 | $ | 5.44 | |||||
PAI,
LLC
|
5/4/2010
|
Sale
|
5,500 | $ | 5.45 | |||||
PAI,
LLC
|
5/5/2010
|
Sale
|
5,200 | $ | 5.61 | |||||
PAI,
LLC
|
5/6/2010
|
Sale
|
100 | $ | 5.50 | |||||
PAI,
LLC
|
5/13/2010
|
Sale
|
5,200 | $ | 4.52 | |||||
PAI,
LLC
|
5/14/2010
|
Sale
|
12,500 | $ | 4.26 | |||||
Small
Cap Master
|
4/12/2010
|
Sale
|
64,200 | $ | 5.27 | |||||
Small
Cap Master
|
4/15/2010
|
Sale
|
9,200 | $ | 5.38 | |||||
Small
Cap Master
|
4/16/2010
|
Sale
|
6,200 | $ | 5.32 | |||||
Small
Cap Master
|
4/19/2010
|
Sale
|
500 | $ | 5.28 | |||||
Small
Cap Master
|
4/20/2010
|
Sale
|
14,100 | $ | 5.24 | |||||
Small
Cap Master
|
4/21/2010
|
Sale
|
4,000 | $ | 5.23 | |||||
Small
Cap Master
|
4/22/2010
|
Sale
|
3,400 | $ | 5.23 | |||||
Small
Cap Master
|
4/23/2010
|
Sale
|
13,200 | $ | 5.28 | |||||
Small
Cap Master
|
4/26/2010
|
Sale
|
13,800 | $ | 5.51 | |||||
Small
Cap Master
|
4/27/2010
|
Sale
|
157,100 | $ | 5.25 | |||||
Small
Cap Master
|
4/28/2010
|
Sale
|
5,000 | $ | 5.35 | |||||
Small
Cap Master
|
4/29/2010
|
Sale
|
4,500 | $ | 5.32 | |||||
Small
Cap Master
|
4/30/2010
|
Sale
|
7,200 | $ | 5.26 | |||||
Small
Cap Master
|
5/3/2010
|
Sale
|
7,300 | $ | 5.44 | |||||
Small
Cap Master
|
5/4/2010
|
Sale
|
12,300 | $ | 5.45 | |||||
Small
Cap Master
|
5/5/2010
|
Sale
|
11,900 | $ | 5.61 | |||||
Small
Cap Master
|
5/6/2010
|
Sale
|
400 | $ | 5.50 | |||||
Small
Cap Master
|
5/7/2010
|
Sale
|
200 | $ | 5.07 | |||||
Small
Cap Master
|
5/13/2010
|
Sale
|
12,100 | $ | 4.52 | |||||
Small
Cap Master
|
5/14/2010
|
Sale
|
28,600 | $ | 4.26 |
PALO
ALTO INVESTORS, INC.
By: /s/ Mark
Shamia
Mark Shamia, Chief Operating
Officer
|
PALO
ALTO INVESTORS, LLC
By: /s/ Mark
Shamia
Mark Shamia, Chief Operating
Officer
|
PALO
ALTO SMALL CAP MASTER FUND, L.P.
By: Palo
Alto Investors, LLC, General Partner
By: Palo
Alto Investors, Manager
By: /s/ Mark
Shamia
Mark Shamia, Chief Operating
Officer
|
PALO
ALTO SMALL CAP FUND, L.P.
By: Palo
Alto Investors, LLC, General Partner
By: Palo
Alto Investors, Manager
By: /s/ Mark
Shamia
Mark Shamia, Chief Operating
Officer
|
/s/
Anthony Joonkyoo
Yun
Anthony Joonkyoo Yun,
MD
|
/s/
William Leland
Edwards
William Leland
Edwards
|