UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

                                    FORM 8-K

                                 CURRENT REPORT
                     PURSUANT TO SECTION 13 OR 15(D) OF THE
                         SECURITIES EXCHANGE ACT OF 1934



       Date of Report (Date of earliest event reported): December 8, 2006

                               CELGENE CORPORATION
             (Exact name of registrant as specified in its charter)


           Delaware                        0-16132                22-2711928
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(State or other jurisdiction of    (Commission File Number)     (IRS Employer
        incorporation)                                       Identification No.)

      86 Morris Avenue, Summit, New Jersey                       07901
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    (Address of principal executive offices)                   (Zip Code)

       Registrant's telephone number, including area code: (908) 673-9000


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         (Former name or former address, if changed since last report.)

Check the appropriate box below if the Form 8-K filing is intended to
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|_|  Written communications pursuant to Rule 425 under the Securities Act (17
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|_|  Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR
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     Exchange Act (17 CFR 240.14d-2(b))

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     Exchange Act (17 CFR 240.13e-4(c))



ITEM 1.01     ENTRY INTO A MATERIAL DEFINITIVE AGREEMENT.

On December 11, 2006, Celgene Corporation, or the Company, announced that on
December 8, 2006 it entered into a material definitive agreement for the
purchase of an active pharmaceutical ingredient (API) manufacturing facility
from Siegfried Ltd. located in Zofingen, Switzerland, and simultaneously
consummated such purchase. The Company is purchasing the assets for
approximately a total of $46.5 million in cash, with an initial payment of $12.5
million. The manufacturing facility has the capability to produce multiple drug
substances and initially will be used to produce REVLIMID(R) to supply global
markets.

Attached hereto as Exhibit 99.1 is the Press Release announcing the transaction.


ITEM 9.01   FINANCIAL STATEMENTS AND EXHIBITS.

Exhibit 99.1    Press Release dated December 11, 2006 announcing the acquisition
                of an API manufacturing facility from Siegfried Ltd.


                                   SIGNATURES

Pursuant to the requirements of the Securities and Exchange Act of 1934, the
Registrant has duly caused this report to be signed on its behalf by the
undersigned hereunto duly authorized.

                                           CELGENE CORPORATION


Date:  December 12, 2006                   By: /s/ Robert J. Hugin
                                           -----------------------------------
                                               Name:  Robert J. Hugin
                                               Title: President and
                                                      Chief Operating Officer




EXHIBIT INDEX

Exhibit No.          Description
-----------          -----------

Exhibit 99.1         Press Release dated December 11, 2006 announcing the
                     acquisition of an API manufacturing facility from
                     Siegfried Ltd.