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Schrödinger Reports Strong First Quarter 2023 Financial Results

Delivered First Quarter Total Revenue of $64.8 Million, Driven by Strong Drug Discovery Revenue of $32.6 Million

Reports First Subjects Enrolled in Both Ongoing Phase 1 Study of MALT1 Inhibitor SGR-1505 and Newly Initiated Phase 1 Study in Healthy Subjects

Cash Position Significantly Strengthened by $147.3 Million Distribution from Sale of Nimbus’s TYK2 Inhibitor to Takeda

Schrödinger, Inc. (Nasdaq: SDGR), whose physics-based computational platform is transforming the way therapeutics and materials are discovered, today announced financial results for the first quarter ended March 31, 2023.

“We are very pleased with our achievements during the first quarter, which included strong contributions from our software business and our drug discovery collaborations,” stated Ramy Farid, Ph.D., chief executive officer of Schrödinger. “We are making excellent progress across our pipeline of proprietary and collaborative programs. We advanced the first program in our collaboration with BMS to development candidate status, and today reported that we have begun enrollment and dosing in both our ongoing Phase 1 study of SGR-1505 in patients with advanced B cell malignancies and our newly-initiated Phase 1 study in healthy volunteers. The transition to being a clinical-stage company represents a significant milestone for Schrödinger and an important step toward delivering our medicines to patients.”

“We delivered a very strong quarter, with software and drug discovery making equal contributions to our revenue result, reflecting our balanced business model. We also made substantial progress in both collaborative and proprietary programs and added capital to our balance sheet, and our partners achieved significant corporate and development milestones further validating our platform,” stated Geoff Porges, MBBS, chief financial officer of Schrödinger. “With our highly differentiated technology, our growing pipeline and our strong cash position, we are well positioned to achieve our goals for 2023 and beyond.”

First Quarter 2023 GAAP Financial Results

  • Total revenue for the first quarter increased 33% to $64.8 million, compared to $48.7 million in the first quarter of 2022.
  • Software revenue for the first quarter was $32.2 million, compared to $33.1 million in the first quarter of 2022. Software revenue in the first quarter of 2023 included a small number of multi-year agreements that did not fully offset revenue from multi-year agreements in the first quarter of 2022.
  • Drug discovery revenue was $32.6 million for the first quarter and included a $25 million milestone from BMS, compared to $15.6 million in the first quarter of 2022.
  • Software gross margin increased to 78% for the first quarter, compared to 77% in the first quarter of 2022.
  • Operating expenses were $76.2 million for the first quarter, compared to $56.6 million for the first quarter of 2022. The increase was driven by additional headcount to support the company’s progressing internal pipeline and its software business, CRO expenses, and royalties.
  • Other income for the first quarter was $186.0 million, primarily associated with changes in fair value of equity investments, interest income, and a $147.3 million gain relating to the cash distributions from Nimbus in connection with the sale of Nimbus’s TYK2 inhibitor to Takeda. Other expense for the first quarter of 2022 was $5.8 million driven primarily by changes in the fair value of the company’s equity investments.
  • Net income for the first quarter was $129.1 million, compared to net loss of $34.4 million in the first quarter of 2022.
  • During the first quarter, Schrödinger reported a non-cash tax expense of $26.4 million associated with the cash distribution from Nimbus.
  • At March 31, 2023, Schrödinger had cash, cash equivalents, restricted cash and marketable securities of approximately $532 million, compared to approximately $456 million at December 31, 2022.

 

Three months ended

March 31,

 

2023

2022

% Change

 

(in millions)

 

Total revenue

$

64.8

 

$

48.7

 

33%

Software revenue

 

32.2

 

 

33.1

 

(3%)

Drug discovery revenue

 

32.6

 

 

15.6

 

109%

Software gross margin

 

78

%

 

77

%

 

 

 

 

 

Operating expenses

$

76.2

 

$

56.6

 

35%

Other income (expense)

$

186.0

 

$

(5.8

)

Net income (loss)

$

129.1

 

$

(34.4

)

For the three months ended March 31, 2023, Schrödinger reported a non-GAAP net loss of $27.5 million compared to a non-GAAP net loss of $28.3 million for the three months ended March 31, 2022. See “Non-GAAP Information” below and the table at the end of this press release for a reconciliation of non-GAAP net income (loss) to GAAP net income (loss).

2023 Financial Outlook

As of May 4, 2023, Schrödinger maintained its financial guidance for the fiscal year ending December 31, 2023:

  • Software revenue growth is expected to be in the range of 13 to 17 percent
  • Drug discovery revenue is expected to range from $70 million to $90 million
  • Software gross margin is expected to be similar to software gross margin for the full year 2022
  • Operating expense growth in 2023 is expected to be significantly lower than operating expense growth in 2022 and to be similar to revenue growth in 2023
  • Cash used for operating activities in 2023 is expected to be below cash used for operating activities in 2022

For the second quarter of 2023, software revenue is expected to range from $27 million to $31 million.

Recent Highlights

Corporate

  • In April, Schrödinger received a $36.0 million distribution, which is the second cash distribution from Nimbus Therapeutics in connection with Takeda’s acquisition of Nimbus Lakshmi, Inc., a wholly-owned subsidiary of Nimbus, and its tyrosine kinase 2 (TYK2) inhibitor, NDI-034858. Schrödinger received the first distribution of $111.3 million in February 2023 for a total distribution of approximately $147.3 million, all of which was recognized as other income in the company’s first quarter 2023 financial results. NDI-034858 is being evaluated for the treatment of multiple autoimmune diseases following positive Phase 2b results in psoriasis.
  • In April, Schrödinger published its inaugural corporate sustainability report. The report highlights the company's vision and approach to corporate sustainability, summarizes the company’s 2022 achievements and discloses key data about its corporate sustainability efforts in alignment with GRI and SASB reporting standards.

Pipeline

  • Schrödinger continues to advance its MALT1 inhibitor, SGR-1505, in Phase 1 clinical development. A dose-escalation study designed to evaluate the safety, pharmacokinetics, pharmacodynamics, and early signals of clinical activity of SGR-1505 as a monotherapy is ongoing in patients with relapsed or refractory B-cell malignancies. Today Schrödinger announced that it has also initiated a Phase 1 study in healthy subjects to evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of SGR-1505.
  • Schrödinger is continuing to progress its CDC7 inhibitor, SGR-2921, through IND-enabling studies to support a planned IND submission in the first half of 2023. SGR-2921 has exhibited strong anti-tumor activity as a monotherapy and in combination with standard of care agents in multiple preclinical tumor models.
  • Schrödinger continues to advance its Wee1 inhibitor, SGR-3515, through IND-enabling studies to support a potential IND submission in 2024.
  • Schrödinger continues to advance its multi-target collaboration with BMS and today announced that it received a $25 million milestone payment associated with the advancement of the SOS1/KRAS program to development candidate status. This payment was recognized in drug discovery revenue in the first quarter of 2023.
  • Schrödinger’s collaborator, Morphic Therapeutic, made significant progress advancing MORF-057, an oral α4β7 integrin inhibitor, reporting positive topline results of the EMERALD-1 Phase 2a study in adults with moderate to severe ulcerative colitis (UC). MORF-057 achieved the primary endpoint and demonstrated consistent clinical improvement across other key measures with a favorable tolerability profile.
  • The company continues to progress a pipeline of early-stage wholly-owned programs with potential across a broad range of therapeutic areas. Schrödinger is planning to review its drug discovery programs during its Pipeline Day, a virtual and in-person event that will take place on September 28, 2023.

Platform

  • Schrödinger scientists published research showing how the company’s computational methods can be used to refine AlphaFold2 structures for hit discovery. While the publication of the open source AlphaFold protein structure database covers the complete human proteome and represents a significant scientific advance, computational methods are required to adequately refine the AlphaFold structures to improve their utility for drug discovery.
  • Schrödinger scientists published a study describing how FEP+ can be used with homology models for protein thermostability predictions, which can extend Schrödinger’s platform and the use of FEP+ thermostability prediction to targets for which an experimental structure is unavailable. Protein engineering for thermostability has a range of applications, including in the design of antibodies and in chemical industries where protein stability requires optimization to enable enzymes to withstand specific chemical conditions or to extend the shelf-life of protein products.

Webcast and Conference Call Information

Schrödinger will host a conference call to discuss its first quarter 2023 financial results on Thursday, May 4, 2023, at 4:30 p.m. ET. The live webcast can be accessed under "News & Events" in the investors section of Schrödinger’s website, https://ir.schrodinger.com/news-and-events/event-calendar. To access the call by phone, please dial 1-888-396-8049 (domestic) or 1-416-764-8646 (international) and refer to conference ID 21402709. The archived webcast will be available on Schrödinger’s website for approximately 90 days following the event.

Non-GAAP Information

Included in this press release is certain financial information that has not been prepared in accordance with generally accepted accounting principles in the United States (GAAP). The company presents non-GAAP net income (loss) and non-GAAP net income (loss) per share, which exclude gains and losses on equity investments, changes in fair value, and non-cash income tax benefits and expenses relating to the company’s gains and losses on equity investments. Adjusting net income to exclude the impact of these items results in a financial presentation for the company without the impact of our equity investments. Management believes non-GAAP net income (loss) and non-GAAP net income (loss) per share are useful measures for investors, taken in conjunction with the company’s GAAP financial statements because they provide greater period-over-period comparability with respect to the company’s operating performance, by excluding non-cash mark-to-market and other valuation adjustments for our equity investments, non-recurring cash distributions from our equity investments and the tax impact of these distributions that are not reflective of the ongoing operating performance of the business. However, the non-GAAP measures should be considered only in addition to, not as a substitute for or as superior to, net income (loss) and net income (loss) per share or other financial measures prepared in accordance with GAAP.

Other companies in our industry may calculate non-GAAP net income (loss) and non-GAAP net income (loss) per share, differently than we do, limiting their usefulness as comparative measures. For a reconciliation of non-GAAP net income (loss) and non-GAAP net income (loss) per share to GAAP net income (loss) and GAAP net income (loss) per share, respectively, please refer to the tables at the end of this press release.

About Schrödinger

Schrödinger is transforming the way therapeutics and materials are discovered. Schrödinger has pioneered a physics-based computational platform that enables discovery of high-quality, novel molecules for drug development and materials applications more rapidly and at lower cost compared to traditional methods. The software platform is licensed by biopharmaceutical and industrial companies, academic institutions, and government laboratories around the world. Schrödinger’s multidisciplinary drug discovery team also leverages the software platform to advance a portfolio of collaborative and proprietary programs to address unmet medical needs.

Founded in 1990, Schrödinger has approximately 800 employees and is engaged with customers and collaborators in more than 70 countries. To learn more, visit www.schrodinger.com, follow us on LinkedIn and Instagram, or visit our blog, Extrapolations.com.

Cautionary Note Regarding Forward-Looking Statements

This press release contains forward-looking statements within the meaning of The Private Securities Litigation Reform Act of 1995 including, but not limited to those statements regarding Schrödinger’s expectations about the speed and capacity of its computational platform, its financial outlook for the fiscal year ending December 31, 2023 and second quarter ending June 30, 2023, its plans to continue to invest in research and its strategic plans to accelerate the growth of its software licensing business and advance its collaborative and proprietary drug discovery programs, the long-term potential of its business, its ability to improve and advance the science underlying its platform, the initiation, timing, progress, and results of its proprietary drug discovery programs and product candidates and the drug discovery programs and product candidates of its collaborators, the clinical potential and favorable properties of its CDC7, MALT1, and Wee1 inhibitors, including SGR-1505, SGR-2921, and SGR-3515, the clinical potential and favorable properties of its collaborators’ product candidates, as well as expectations related to the use of its cash, cash equivalents and marketable securities. Statements including words such as “aim,” “anticipate,” “believe,” “contemplate,” “continue,” “could,” “estimate,” “expect,” “goal,” “intend,” “may,” “might,” “plan,” “potential,” “predict,” “project,” “should,” “target,” “will,” “would” and statements in the future tense are forward-looking statements. These forward-looking statements reflect Schrödinger’s current views about its plans, intentions, expectations, strategies and prospects, which are based on the information currently available to the company and on assumptions the company has made. Actual results may differ materially from those described in these forward-looking statements and are subject to a variety of assumptions, uncertainties, risks and important factors that are beyond Schrödinger’s control, including the demand for its software platform, its ability to further develop its computational platform, its reliance upon third-party providers of cloud-based infrastructure to host its software solutions, factors adversely affecting the life sciences industry, fluctuations in the value of the U.S. dollar and foreign currencies, its reliance upon its third-party drug discovery collaborators, the uncertainties inherent in drug development and commercialization, such as the conduct of research activities and the timing of and its ability to initiate and complete preclinical studies and clinical trials, whether results from preclinical studies will be predictive of the results of later preclinical studies and clinical trials, uncertainties associated with the regulatory review of IND submissions, clinical trials and applications for marketing approvals, the ability to retain and hire key personnel and the direct and indirect impacts of the ongoing COVID-19 pandemic on its business and other risks detailed under the caption “Risk Factors” and elsewhere in the company’s Securities and Exchange Commission filings and reports, including its Quarterly Report on Form 10-Q for the fiscal quarter ended March 31, 2023, filed with the Securities and Exchange Commission on May 4, 2023, as well as future filings and reports by the company. Any forward-looking statements contained in this press release speak only as of the date hereof. Except as required by law, Schrödinger undertakes no duty or obligation to update any forward-looking statements contained in this press release as a result of new information, future events, changes in expectations or otherwise.

Condensed Consolidated Statements of Operations (Unaudited)

(in thousands, except for share and per share amounts)

 

 

Three months ended March 31,

 

2023

 

2022

Revenues:

 

 

 

Software products and services

$

32,213

 

 

$

33,081

 

Drug discovery

 

32,569

 

 

 

15,582

 

Total revenues

 

64,782

 

 

 

48,663

 

Cost of revenues:

 

 

 

Software products and services

 

7,115

 

 

 

7,511

 

Drug discovery

 

11,974

 

 

 

13,169

 

Total cost of revenues

 

19,089

 

 

 

20,680

 

Gross profit

 

45,693

 

 

 

27,983

 

Operating expenses:

 

 

 

Research and development

 

40,741

 

 

 

27,822

 

Sales and marketing

 

9,145

 

 

 

6,671

 

General and administrative

 

26,308

 

 

 

22,133

 

Total operating expenses

 

76,194

 

 

 

56,626

 

Loss from operations

 

(30,501

)

 

 

(28,643

)

Other income (expense):

 

 

 

Gain on equity investments

 

147,322

 

 

 

 

Change in fair value

 

35,737

 

 

 

(6,164

)

Other income

 

2,937

 

 

 

339

 

Total other income (expense)

 

185,996

 

 

 

(5,825

)

Income (loss) before income taxes

 

155,495

 

 

 

(34,468

)

Income tax expense (benefit)

 

26,359

 

 

 

(28

)

Net income (loss)

 

129,136

 

 

 

(34,440

)

Net income (loss) per share of common and limited common stockholders, basic:

$

1.81

 

 

$

(0.48

)

Weighted average shares used to compute net income (loss) per share of common and limited common stockholders, basic:

 

71,467,097

 

 

 

71,050,432

 

Net income (loss) per share of common and limited common stockholders, diluted:

$

1.75

 

 

$

(0.48

)

Weighted average shares used to compute net income (loss) per share of common and limited common stockholders, diluted:

 

73,818,611

 

 

 

71,050,432

 

 

Condensed Consolidated Balance Sheets (Unaudited)

(in thousands, except for share and per share amounts)

 

Assets

March 31, 2023

 

December 31,

2022

Current assets:

 

 

 

Cash and cash equivalents

$

233,206

 

 

$

90,474

 

Restricted cash

 

4,486

 

 

 

5,243

 

Marketable securities

 

294,482

 

 

 

360,613

 

Accounts receivable, net of allowance for doubtful accounts of $125 and $125

 

46,691

 

 

 

55,953

 

Unbilled and other receivables, net for allowance for unbilled receivables of $100 and $100

 

13,473

 

 

 

13,137

 

Prepaid expenses

 

11,396

 

 

 

8,569

 

Total current assets

 

603,734

 

 

 

533,989

 

Property and equipment, net

 

16,493

 

 

 

14,244

 

Equity investments

 

101,539

 

 

 

25,683

 

Goodwill

 

4,791

 

 

 

4,791

 

Intangible assets, net

 

 

 

 

587

 

Right of use assets

 

105,982

 

 

 

105,982

 

Other assets

 

6,234

 

 

 

3,311

 

Total assets

$

838,773

 

 

$

688,587

 

Liabilities and Stockholders' Equity:

 

 

 

Current liabilities:

 

 

 

Accounts payable

$

11,987

 

 

$

9,470

 

Income taxes payable

 

26,318

 

 

 

355

 

Accrued payroll, taxes, and benefits

 

13,152

 

 

 

24,882

 

Deferred revenue

 

51,578

 

 

 

57,931

 

Lease liabilities

 

11,810

 

 

 

11,006

 

Other accrued liabilities

 

8,562

 

 

 

5,166

 

Total current liabilities

 

123,407

 

 

 

108,810

 

Deferred revenue, long-term

 

20,348

 

 

 

25,598

 

Lease liabilities, long-term

 

104,058

 

 

 

105,485

 

Other liabilities, long-term

 

700

 

 

 

800

 

Total liabilities

 

248,513

 

 

 

240,693

 

Stockholders' equity:

 

 

 

Preferred stock, $$0.01 par value. Authorized 10,000,000 shares; zero shares issued and outstanding at March 31, 2023 and December 31, 2022, respectively

 

 

 

 

 

Common stock, $$0.01 par value. Authorized 500,000,000 shares; 62,362,015 and 62,163,739 shares issued and outstanding at March 31, 2023 and December 31, 2022 , respectively

 

623

 

 

 

622

 

Limited common stock, $$0.01 par value. Authorized 100,000,000 shares; 9,164,193 shares issued and outstanding at March 31, 2023 and December 31, 2022, respectively

 

92

 

 

 

92

 

Additional paid-in capital

 

840,446

 

 

 

828,700

 

Accumulated deficit

 

(250,002

)

 

 

(379,138

)

Accumulated other comprehensive loss

 

(899

)

 

 

(2,382

)

Total stockholders' equity of Schrödinger stockholders

 

590,260

 

 

 

447,894

 

Total liabilities and stockholders' equity

$

838,773

 

 

$

688,587

 

 

Condensed Consolidated Statements of Cash Flows (Unaudited)

(in thousands)

 

 

Three Months Ended March 31,

 

2023

 

2022

Cash flows from operating activities:

 

 

 

Net income (loss)

$

129,136

 

 

$

(34,440

)

Adjustments to reconcile net income (loss) to net cash used in operating activities:

 

 

 

Gain on equity investments

 

(147,322

)

 

 

 

Fair value adjustments

 

(35,737

)

 

 

6,164

 

Depreciation and amortization

 

1,760

 

 

 

969

 

Stock-based compensation

 

10,880

 

 

 

9,134

 

Noncash investment (accretion) amortization

 

(964

)

 

 

1,504

 

Gain on disposal of property and equipment

 

 

 

 

(4

)

Decrease (increase) in assets, net of acquisition:

 

 

 

Accounts receivable, net

 

9,262

 

 

 

2,935

 

Unbilled and other receivables

 

(336

)

 

 

(7,390

)

Reduction in the carrying amount of right of use assets

 

 

 

 

1,221

 

Prepaid expenses and other assets

 

(5,750

)

 

 

(7,725

)

Increase (decrease) in liabilities, net of acquisition:

 

 

 

Accounts payable

 

2,468

 

 

 

1,328

 

Income taxes payable

 

25,963

 

 

 

43

 

Accrued payroll, taxes, and benefits

 

(11,730

)

 

 

(7,454

)

Deferred revenue

 

(11,603

)

 

 

(7,079

)

Lease liabilities

 

(623

)

 

 

489

 

Other accrued liabilities

 

3,502

 

 

 

594

 

Net cash used in operating activities

 

(31,094

)

 

 

(39,711

)

Cash flows from investing activities:

 

 

 

Purchases of property and equipment

 

(3,580

)

 

 

(1,696

)

Purchases of equity investments

 

(4,125

)

 

 

 

Distribution from equity investment

 

111,329

 

 

 

 

Acquisition, net of acquired cash

 

 

 

 

(6,427

)

Purchases of marketable securities

 

(58,823

)

 

 

(55,068

)

Proceeds from maturity of marketable securities

 

127,401

 

 

 

99,495

 

Net cash provided by investing activities

 

172,202

 

 

 

36,304

 

Cash flows from financing activities:

 

 

 

Issuances of common stock upon stock option exercises

 

867

 

 

 

908

 

Contribution by noncontrolling interest

 

 

 

 

 

Net cash provided by financing activities

 

867

 

 

 

908

 

Net increase (decrease) in cash and cash equivalents and restricted cash

 

141,975

 

 

 

(2,499

)

Cash and cash equivalents and restricted cash, beginning of period

 

95,717

 

 

 

123,267

 

Cash and cash equivalents and restricted cash, end of period

$

237,692

 

 

$

120,768

 

 

 

 

 

Supplemental disclosure of cash flow and noncash information

 

 

 

Cash paid for income taxes

$

86

 

 

$

37

 

Supplemental disclosure of non-cash investing and financing activities

 

 

 

Purchases of property and equipment in accounts payable

 

218

 

 

 

317

 

Purchases of property and equipment in accrued liabilities

 

86

 

 

 

343

 

Acquisition of right to use assets, contingency resolution

 

1,820

 

 

 

1,513

 

Acquisition of right of use assets

 

 

 

 

1,146

 

Acquisition of lease liabilities

 

 

 

 

1,146

 

 

Reconciliation of GAAP to Non-GAAP Financial Measures (Unaudited)

 

 

Three Months Ended

March 31,

 

2023

 

2022

 

(in thousands, except per share data)

Net income (loss) (GAAP)

$

129,136

 

 

$

(34,440

)

Income tax expense (benefit)

 

26,359

 

 

 

 

Gain on equity investments

 

(147,322

)

 

 

 

Change in fair value

 

(35,737

)

 

 

6,164

 

Non-GAAP net loss

$

(27,564

)

 

$

(28,276

)

Non-GAAP net income (loss) per share of common and limited common stockholders, basic and diluted

$

(0.38

)

 

$

(0.40

)

 

 

 

 

 

 

 

 

 

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