SHANGHAI and CAMBRIDGE, Mass., April 11, 2023 (GLOBE NEWSWIRE) -- Zai Lab Limited (NASDAQ: ZLAB; HKEX: 9688) will present new data including a translational and biomarker data analysis from its internal oncology discovery program ZL-1211 at the upcoming 2023 American Association for Cancer Research (AACR) Annual Meeting in Orlando on April 14-19, 2023. ZL-1211 is an anti-CLDN18.2 antibody currently in a Phase 1 clinical trial for advanced solid tumors (NCT05065710).
ZL-1211 targets CLDN18.2 to induce cancer cell death through antibody-dependent cellular cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC). In preclinical studies, Zai Lab developed and validated ADCC and CDC assays for ZL-1211. This presentation will feature results generated from clinical patient samples using these assays to support the mechanism of action for ZL-1211.Several potential predictive biomarkers from preclinical in vitro and in vivo analyses will be highlighted in the presentation. These novel biomarkers have the potential to further enrich patient selection in the ZL-1211 Phase 1 trial.
“This presentation at AACR supports the clinical development of ZL-1211 targeting advanced solid tumors, while also demonstrating the growth of our global internal oncology pipeline,” said Rafael Amado, MD, President, Head of Global Oncology Research and Development, Zai Lab. “We will continue to invest in advancing our oncology programs, focused on addressing the high unmet patient needs in cancer worldwide.”
In addition, Zai will be presenting a second poster presentation about tebotelimab, a PD-1/LAG-3 bispecific antibody. Details regarding the two Zai Lab presentations at 2023 AACR are as follows:
Title: Clinical Translation of Biomarkers for ZL-1211, an Anti-CLDN18.2 Antibody, in Patients with Advanced Solid Tumors from a Phase I Dose-Escalation Study
Abstract number: 4531
Date and time: Tuesday, April 18, 2023, 9:00 AM – 12:30 PM ET
Location: Section 44, Poster #10
Title: Tebotelimab, a PD-1/LAG-3 bispecific antibody, in patients with untreated, unresectable, recurrent or metastatic, mucosal melanoma: An open-label, single-arm, Phase 1 study
Abstract number: CT208
Date and time: Tuesday Apr 18, 2023; 9:00 AM - 12:30 PM
Location: Section 46, Poster #21
About Zai Lab
Zai Lab Limited (NASDAQ: ZLAB; HKEX: 9688) is an innovative, research-based, commercial-stage biopharmaceutical company based in China and the United States focused on bringing transformative medicines for oncology, autoimmune disorders, infectious diseases, and neurological disorders to patients in China and around the world. Our goal is to leverage our competencies and resources to positively impact human health worldwide.
For additional information about Zai Lab, including our products, business activities and partnerships, research, and other events or developments, please visit www.zailaboratory.com or follow us at www.twitter.com/ZaiLab_Global.
Zai Lab Forward-Looking Statements
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Investor Relations: Lina Zhang
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Zai Lab Limited